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Alzheimer’s disease

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Alzheimer’s Tau protein forms toxic complexes with cell membranes

22 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers identify the sequence and structural factors that drive Tau interaction with membranes...

news

SORLA protein protects against Alzheimer’s disease

7 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...

news

Declines in plasticity reveal promising targets for Alzheimer’s disease

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

Brain changes linked to memory loss may provide a new focus for exploring ways to treat or prevent dementia...

news

yTRAP used to quantitatively measure and manipulate protein aggregation

23 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have built a synthetic genetic tool yTRAP to quantitatively sense, measure and manipulate protein aggregation in live cells...

news

Discovery lights path for Alzheimer’s research

19 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers identify binding site on the amyloid beta peptide that could facilitate better drugs to treat the disease...

news

Phenogenetic map created for stem cell models of neurological diseases

19 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have performed meta-analysis of neurological and neurodegenerative diseases and created an atlas of how cell characteristics are linked to their genotype...

news

Cryo-MOST approach maps whole-brain changes in Alzheimer’s disease

18 October 2017 | By Nic Losardo (Drug Target Review)

Micron-level, 3-D visualisation of protein deposits found in Alzheimer's disease could speed development of new treatments...

news

TREM2 gene mutation poses both risk and benefits in Alzheimer’s disease

9 October 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified that a mutation in the gene TREM2, can substantially raise a person’s risk of Alzheimer’s disease...

news

Microcapsules to enhance the efficiency of genome-editing

6 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...

news

Metabolic collaboration linked to Alzheimer’s disease

29 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration...

news

Blocking ApoE4 may prevent nerve cell death in Alzheimer’s disease

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified that the presence of ApoE4 exacerbates the brain damage caused by toxic tangles of tau protein...

news

Structure of amyloid fibrils determined with previously unachieved resolution

11 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have displayed structural details of amyloid structures which may answer many questions on the growth of harmful deposits...

article

Calcilytics as potential novel therapeutic treatments to halt Alzheimer’s disease

7 September 2017 | By Dr Anna Chiarini, Dr Ilaria Dal Prà, Prof Ubaldo Armato

Alzheimer’s disease (AD) is the most prevalent form of dementia.1 The common (>95% of cases) slow-developing form of the ailment is known as late-onset AD (LOAD) or sporadic AD (SAD). The rare (

news

New mindset in the search for stroke therapies

7 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a promising new avenue to explore in the search for stroke treatments...

article

Drug Target Review – Issue #3 2017

6 September 2017 | By Drug Target Review

Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...

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Alzheimer’s disease