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antibiotic resistance

Chain of amino acid or bio molecules called protein - 3d illustration

Nobel Prize celebrates AI’s role in protein structure innovation

9 December 2024 | By Roberta Sher

The 2024 Nobel Prize in Chemistry honours AI's transformative impact on protein science, with breakthroughs set to reshape drug development.

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Increased persister cells production leads to antibiotic resistance

15 January 2024 | By Drug Target Review

Using clinical E. coli bacteraemia isolates, researchers found that high-persister mutants evolved which contributed to antibiotic failure.

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New shape-shifting antibiotics could solve drug-resistant bacteria

6 April 2023 | By Izzy Wood (Drug Target Review)

US scientists have developed antibiotics that can “shape-shift”, which prevent bacteria from coming resistant against them.

Coronavirus vaccine development in science laboratory concept vector illustration. Cartoon tiny scientist people develop and test new corona virus covid19 vaccine, holding medical equipment background

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Drug Target Review’s top content picks from 2022

13 December 2022 | By Izzy Wood (Drug Target Review), Ria Kakkad (Drug Target Review)

In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.

Close up of a light microscopy being used by a researcher - image shows just the metal lens and table with slide on

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What is new in the world of imaging?

21 January 2021 | By Hannah Balfour (Drug Target Review)

In this article, Drug Target Review’s Hannah Balfour discusses three of the latest developments in imaging for disease research and drug development.

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Discovering the mechanisms of antibiotic resistance could lead to better drugs

20 January 2021 | By Hannah Balfour (Drug Target Review)

A single change to the structure of bacterial ribosomes prevents macrolide antibiotics from binding and killing the bacteria, according to a study.

Wasp on a wooden platform [Credit: University of Pennsylvania].

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Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

MRSA colonies in yellow on a dark blue background

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Novel lysin-based antibacterial agent could help combat MRSA

7 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers have engineered F12, a lysin-based antibacterial drug, to have limited negative side-effects and so it can be administered repeatedly without loss of efficacy.

long and thin streptococcus pneumoniae bacteria in the lungs

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Blocking bacterial competence could prevent antibiotic resistance

4 March 2020 | By Hannah Balfour (Drug Target Review)

Scientists suggest competence-blocking, ‘anti-evolution’ drugs could be administered alongside antibiotics to prolong the period before bacterial resistance emerges.

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Metal-based fragment molecule library to screen for drug candidates

20 January 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a novel metal-based fragment library of molecules that can be used to screen for new drug candidates.

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Spined soldier bug can be used to develop new classes of antibiotics

15 November 2018 | By Drug Target Review

Researchers have identified the mechanism by which thanatin attacks the way the outer membrane of Gram-negative bacteria is built...

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CHAOS approach to antibiotic resistance

4 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...

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Genetic catalyst identifies the evolution of antibiotic resistance

26 April 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have shown that it is possible to identify genetic catalysts that accelerate the evolution of antibiotic resistance in bacteria...

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antibiotic resistance