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Scientists uncover steps to kinase enzyme activation
A new study by the University of Arizona (UA) suggests that revealing all the steps required to activate an enzyme called a protein kinase may help identify new ways to target cancer.
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Penn study finds that different diseases elicit distinct sets of exhausted T cells
Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.
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Researchers uncover up to 100 potential drug targets for cancer
In a new study based on mouse cells, researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.
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mEAK-7 gene could suggest path towards cancer therapies
Researchers have found mEAK-7 regulates the molecular process that dictates cell growth and human development...
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Tumour-like spheres help scientists discover smarter cancer drugs
Researchers are reporting an innovative new method to screen for potential cancer drugs...
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Elastic microspheres expand understanding of embryonic development and cancer cells
A new technique that uses tiny elastic balls filled with fluorescent nanoparticles aims to expand the understanding of the mechanical forces that exist between cells...
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Study offers new approach to starve p53 deficient tumours
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
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Taking the brakes off the immune system: modelling effects in non-clinical safety studies
This article focuses on how the immune system functions, the challenges that it presents to drug development and why there are such concerns around safety that need to be investigated in pre-clinical studies. Moreover, it covers the role of checkpoint inhibitors as an attractive target for cancer immunotherapy.
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New insights into the origins of mutations in cancer
Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
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Obesity inhibits key cancer defence mechanism
Obesity could enhance cancer development while aspirin might prevent it - a new insight into potential targets for cancer prevention.
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GLUT5 fluorescent probe fingerprints cancer cells
Researchers have explained the basic science behind multicolour probes that enable targeting of cancer-relevant fructose transporter, delving into the image-based detection of cancer cells...
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New study discovers cancer-relevant protein shield
Researchers have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment...
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Man-made antibodies show promise in attacking cancer cells in animal models
Molecules called aptamers could form new, safer chemotherapy delivery systems...
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New class of drugs could help tackle treatment-resistant cancers
Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies...
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An advance for precision medicine
Discovery allows scientists to index thousands of cells simultaneously, a 40-fold increase from the current method...
