news
Charles River Laboratories acquires Agilux Laboratories, Inc.
13 October 2016 | By Charles River Laboratories
Enhances Charles River’s early-stage capabilities in bioanalytical services...
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Imaging
whitepaper
Whitepaper: Uncover specific correlations in heterogeneous cell populations during drug development
Integrating the S3e™ Cell Sorter into sample preparation upstream of the QX200™ Droplet Digital System provided details about cell subpopulations that would have been undetectable in heterogeneous populations...
news
How the anthrax toxin forms a deadly “conveyer belt”
28 September 2016 | By Niamh Louise Marriott, Digital Content Producer
During anthrax infections, the bacterium Bacillus anthracis secretes a toxin consisting of two related enzymes named lethal factor and edema factor...
news
Charles River Laboratories and The Tri-Insitutional Therapeutics Discovery Institute announce strategic partnership
26 September 2016 | By Charles River Laboratories
Partnership intends to accelerate translation of discoveries into novel therapies for patients...
article
Imaging In-Depth Focus 2016
In this Imaging In-Depth Focus: Norman Peterson, from MedImmune/AstraZeneca, looks at the practical application of in vivo optical imaging in biotherapeutic biodistribution analyses. Plus, experts from MRC Technology discuss high-content imaging in drug discovery, and Molecular Devices feature in our Q&A...
news
Intercontinental consortium granted €5.1 million to develop breast cancer imaging devices
15 September 2016 | By Niamh Louise Marriott, Digital Content Producer
Grants of more than €5 million, predominantly from the EU, will be used to develop a new imaging device for the diagnosis of breast cancer...
article
Practical application of in vivo optical imaging in biotherapeutic biodistribution analyses
As advances in protein engineering technology have led to the production of novel and more structurally complex biopharmaceuticals, the ability of these drugs to smoothly traverse the body and arrive at their intended target site has become more unpredictable...
article
A picture is worth a thousand endpoints: high-content imaging in drug discovery
Over the past few years several factors in the drug discovery industry have come together to drive an increased interest and subsequent surge in the use of high-content imaging. These include the high costs of attrition in the clinic due to lack of efficacy; increased hurdles and rising costs to…
news
Charles River Laboratories announces partnership with the Milner Therapeutics Institute and Consortium
10 August 2016 | By Charles River Laboratories
Charles River Laboratories announced that it has entered into a strategic partnership with the Milner Therapeutics Institute and Consortium...
product
Bio-Rad CFX96 Touch™ Real-Time PCR Detection System
4 August 2016 | By Bio-Rad Laboratories
The CFX96™ Optical Reaction Module converts the C1000 Touch™ Thermal Cycler chassis into the powerful and precise CFX96 Touch Real-Time PCR Detection System...
news
NanoRacks Plate Reader-2 successfully launched into space
18 July 2016 | By Victoria White, Digital Content Producer
The NanoRacks Plate Reader-2, destined for the International Space Station, allows scientists to conduct life science research in space...
news
Tri-I TDI expands focus to include antibody drug discovery
17 June 2016 | By Victoria White, Digital Content Producer
Tri-I TDI will extend its current relationship with Takeda from the realm of small molecule discovery into the new research area of antibody drug discovery...
news
Super-resolution microscopy reveals the surface of T cells
16 June 2016 | By Victoria White, Digital Content Producer
Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated using super-resolution microscopy...
article
Advanced techniques and applications of LC-MS in small molecule drug discovery
A key process in drug discovery is the ability to identify new drug candidates by screening chemical libraries of small molecules, natural products or extracts against a biological target and selecting lead compounds with desirable therapeutic effects. Medicinal chemistry has the challenging role of not only ensuring that the chemical…
article
Inhibition of RNA-containing viruses by artificial RNases
The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases (artRNases) including peptides, peptidomimetics, N-alkyl-substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) and a silver (I) complex with cystine were analysed for viruses containing single-stranded and double-stranded genomic RNA (the tick-borne encephalitis virus; TBEV and the influenza virus, respectively) in vitro and in vivo by…
