Omics

Counteracting T-cell exhaustion in CAR-T cancer therapies

27 February 2019 | By Iqra Farooq (Drug Target Review)

Engineered T-cells that target NFAT and Nr4a proteins could help to prevent the exhaustion of T-cells during CAR-T immunotherapy...

Genomic approach to studying widespread malaria

11 February 2019 | By Drug Target Review

Researchers have suggested that the most widespread human malaria parasite could be studied and possibly treated using genomics...

Exploring the genome using transcription factors

31 January 2019 | By Drug Target Review

Using transcription factors to explore and understand the genome could lead to the understanding of gene expression patterns...

Identifying the biomedical potential of bivalves

31 January 2019 | By Iqra Farooq (Drug Target Review)

Shellfish, such as oysters, could help to revolutionise human health research by providing insights in cancer therapies and bacterial immunity...

FGL2 protein may be an effective target for GBM

28 January 2019 | By Drug Target Review

Researchers have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance...

Scientists find a cellular process that stops cancer before it starts

24 January 2019 | By Dr Zara Kassam (Drug Target Review)

Salk research shows that cellular recycling process, thought to fuel cancer's growth, can actually prevent it...

Genetic study reveals possible new routes to treating osteoarthritis

23 January 2019 | By Dr Zara Kassam (Drug Target Review)

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...

Molecules associated with NMDAR may be involved in schizophrenia

18 January 2019 | By Dr Zara Kassam (Drug Target Review)

Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...

Scientists developed a new mouse model of Hirschsprung’s disease

17 January 2019 | By Drug Target Review

Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...

GREB1 gene potential drug target for prostate cancer treatment

16 January 2019 | By Drug Target Review

Researchers in the US have discovered how a gene involved in regulating hormone receptors, GREB1, may contribute to drug resistance in some prostate cancer patients.

CRISPR repurposed to develop better antibiotics

14 January 2019 | By Iqra Farooq (Drug Target Review)

Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...

Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models

10 January 2019 | By Taconic Biosciences

Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.

Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice

7 January 2019 | By Taconic Biosciences

Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.

Taconic Biosciences

Proteomics: cracking the molecular mystery of diseases and therapeutics

10 December 2018 | By Anowarul Amin

In the wake of the human genome project, molecular biology and genetic technologies are tremendously integrating into biomedical research. Currently, PCR, qPCR, and sequencing are key tools in the clinical laboratory for the detection and characterisation of microorganisms and genetic disorders.