Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models
Posted: 10 January 2019 | Taconic Biosciences | No comments yet
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
The C57BL/6 mouse – sometimes called the B6 or Black 6 mouse – is among the most useful mouse models in pre-clinical research, owing to its utility in metabolic studies and popularity as a genetic engineering platform.
While the B6 mouse offers many advantages over other mouse models, genetic heterogeneity can present challenges in research design. Within the general B6 mouse strain, there exist several closely-related inbred strains known as substrains. This results in the occasional unwanted genetic heterogeneity when working with multiple substrains of the B6 mouse. However, within each substrain, there is a much higher level of genetic uniformity which leads to greater reproducibility and lower variability in results. In this guide, multiple characteristics of each substrain will be discussed so researchers can choose the model that best fits their research project goals.
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Download this whitepaper to learn:
- Why the B6 is so popular in model design and pre-clinical research
- What health issues and phenotypes exist in which B6 substrains
- How to best leverage B6 mouse model substrains for biomedical research
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