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Application note: A novel way to expedite antibody discovery
Analyse isotype titer and cell health in one assay...
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Screening
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A new therapy proves effective against brain metastasis
The administration of silibinin in patients with brain metastasis reduces lesions without causing any adverse effects, according to a study led by researchers at the Spanish National Cancer Research Centre (CNIO).
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Artificial gene defect reveals target to fight genetic disease
Scientists have deployed a novel genetic screen to search for synthetic viable interactions on special lines of Fanconi Anaemia-defective cells...
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Streamlining drug discovery assays for cancer and cardiovascular disease
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.
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Automated assessment of liver and cardiac toxicities in lead optimisation
This webinar, supported by Tecan, focused on the automated assessment of liver and cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays.
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Expert view: Biological therapeutics are becoming more popular, here are the reasons
For most people, traditional High-Throughput Screening (HTS) represents large automation rigs and large libraries of small molecules screened against drug targets, however, the development of biological therapeutics has been gaining considerable pace for many reasons.
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Expert view: Reviewing the biggest innovations in antibody screening
The demand for new therapeutics is driving efforts to discover novel antibodies and harness their power in both biologics and adoptive cell therapy areas.
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Technical note: 3D volumetric analysis of luminal spaces inside cysts or organoids
High-content assays using 3D objects, such as cysts or organoids, can be challenging from the perspectives of both image acquisition and image analysis.
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Expert view: How high-content platforms keep pace with the changing face of cell-based drug screening
For the next generation of cell biologists, 3D cell culture and analysis has opened doors to taking applied research one step further.
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Expert view: Preparing drug discovery for smart screening era
Advances in genomics and structural biology are providing drug discovery scientists with more biological targets to prosecute, and greater information about each one.
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Product hub: The Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System
Introducing the Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System: the only imaging and analysis platform for advanced performance in screening and analysis.
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Regenerative medicine: enhance cell bioprocessing through cell-based combinatorial culture
Regenerative medicine has emerged as one of the major areas of modern medical therapy. Its primary objective is to restore or establish normal function through the regeneration or replacement of diseased cells, tissues or entire organs. There are a variety of methods and approaches by which this can be achieved.…
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Expert view: High-throughput binding kinetic analysis – is it the new frontier in drug discovery?
Sometimes the difference between identifying a partial or super agonist is only the time point at which the binding reaction is measured.
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Expert view: Improving R&D productivity with novel screening approaches
The pursuit of improved R&D productivity rates coupled with decreased cycle times has dominated pharmaceutical discourse in recent years.
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Supporting the progression of phenotypic hits with bioactivity profiling
Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement.
