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Under the microscope: Choosing the best microplate reader
Efficient microplate readers play an important role in effective hit molecule discovery. Mark Wigglesworth, of AstraZeneca, explains what he looks for in this technology.
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Screening
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Tracking changes in circulating tumour cells shows promise for cancer screening
Researchers in the United States have developed improved methods for capturing circulating tumour cells (CTCs) on clinical samples, with a view to assessing treatment for cancer patients and screening for the disease.
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High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative in vitro immunooncology screening platform
This recent webinar focused on the role of IntelliCyt’s iQue Screener PLUS platform as a high throughput suspension cell screening platform to facilitate simultaneous assessment of multiple parameters, while using minimal sample volumes.
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Expert view: Toward physiological relevance in drug discovery and development
Physiologically relevant screening models have become increasingly important in assay development and the screening of drug candidates.
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Streamlining drug discovery assays for cancer and cardiovascular disease
Declining R&D productivity is a key challenge in the pharmaceutical industry. To increase the success rate of candidate drugs entering the clinical phase, companies must address the early stages of drug discovery.
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Expert view: Screening tools for better lead characterisation
Predictiveness is one of the key factors for success in the drug discovery workflow. Many compounds fail at late stages due to lack of predictive data or the discovery of unwanted side effects.
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Assays In-Depth Focus 2018
In this In-Depth Focus: high throughput strategies for antibody library screening, and the latest in vitro 3D cell and tissue culture model systems in HTS.
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Drug Target Review – Issue #1 2018
In this issue: how customised cell engineering advances immunotherapy, how insights into auto-immunity are providing new opportunities for immune-oncology, and advances in lab automation and robotics are accelerating the pace of antimicrobial therapy.
news
Researchers identify key step in viral replication
Researchers have showed how a common virus hijacks a host cell’s protein to help assemble new viruses before they are released.
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Helmintex assay detects low intensity schistosomiasis infections
Individuals who release low numbers of schistosome eggs in their faeces may now use the Helmintex method-- which uses a magnetic field to isolate eggs to detect infections...
whitepaper
Case Study: Characterisation of hiPSCs by Phenotypic Screening
Case study detailing a simple, highly reproducible phenotypic screen to characterise human induced pluripotent stem cells...
whitepaper
Application Note: Alpha Terbium SureFire Ultra Multiplex: simultaneous dual phosphoprotein target analysis
In this application note, PerkinElmer demonstrates the measurement of two phosphoprotein targets in a single sample using the Alpha Terbium SureFire Ultra kit combined with the AlphaLISA SureFire Ultra kit...
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Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
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Paediatric Clinical Trials
When designing a Paediatric clinical trial, a paediatric investigation plan (PIP) is a development plan aimed at ensuring that the necessary data are obtained through studies in children, to support the authorisation of a medicine for children...
