news
Skeletal stem cells de-differentiate to achieve extensive growth
Researchers in the U.S. have discovered that skeletal stem cells in the jaws of adult mice de-differentiate when tasked with regenerating large portions of bone and tissue.
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Stem Cells
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GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
webinar
Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application
25 October 2018 | By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...
news
Cancer stem cells use normal genes in abnormal ways
Researchers have identified that MHC Class I-high, CDK1 high molecules may be at the heart of conditions including melanoma, pancreatic and colon cancers...
news
Umbilical cord stem cells used for early repair of cleft palate
Stem cells harvested from the umbilical cord after birth could lead to a therapy to treat cleft lip and palate without the traditional surgery...
news
New technique generates brain stem cells more efficiently
Scientists in Ohio have developed a more efficient means of creating brain stem cells, specifically oligodendrocyte progenitor cells, or OPCs, which will help facilitate greater understanding of neurological disorders that result from myelin damage.
news
Oxygen sensitive nanoparticles used for 3D printing of complex tissue-like structures
Researchers have implemented oxygen sensitive nanoparticles into a gel material that can be used for 3D printing of complex, biofilm and tissue-like structures...
article
Expert view: Creating metabolic liabilities to target cancer
As the pace of genetic approaches to combating cancer slows, researchers are focusing on novel approaches to identify and create metabolic liabilities in cells. Cancer cells rewire their metabolism to survive and proliferate rapidly; however, there is no single metabolic phenotype that enables this rewired state.
news
Scientists report using pluripotent stem cells to grow human oesophagal organoids
Scientists have been able to grow human oesophagal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body...
news
Small molecule factors found to influence age-related bone deterioration
Scientists in the U.S. have reported findings about the mechanisms that contribute to the experience of weaker bones with age.
article
Improved screening of therapeutic candidates using integrated fragment-based approaches
An integrated fragment-based approach, which reveals enzymatic inhibitors with potential therapeutic application, is the subject of this webinar.Taking place on 25 October 2018 at 3:00pm, the webinar is supported by NanoTemper Technologies.
article
Expert view: The development of single‑cell genomics with Smart‑seq
Takara Bio has played a major role in the development of single-cell genomics with the launch of kits such as the automation-ready Smart-seq HT, with a simplified 4-steps protocol. In addition, to meetthe demand for using RNA-seq for degraded clinical samples, we have expanded our offering with a complete sequencing…
article
Expert view: Generate high‑content information using flow cytometry
Flow cytometry has become a widely used technology in life science research since its development in the 1970s. It is also essential for many biopharmaceutical and biotechnology companies due to its proficiency in identifying biomarkers, finding new inhibitory antibodies, and assessing the efficiency of new pharmacological protocols.
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Upstream Bioprocessing In-Depth Focus 2018
In this In-Depth Focus: upstream cell culture processes for the production of therapeutic proteins, the evolving role of three-dimensional in-vitro cell culture techniques in drug discovery, and human iPSCs-derived functional cells are revolutionising phenotypic drug discovery and development.
article
Expert view: Multiplexed screens in biologics discovery
Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anti-cancer immunotherapeutics such as checkpoint modulation, adoptive cell therapy and bispecific T-cell engagers. While these approaches use different tactics to attack tumours, they often employ monoclonal antibodies to target…
