The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
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Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
Application note: PHERAstar® measures AlphaScreen assay to develop selective inhibitors for the human YEATS domains
YEATS domains are epigenetic regulators and are recognised as readers of histone post-translational modifications (HPTM) alongside bromodomains, PHD fingers, and others.
This video will show how you can do GPCR binding and signalling studies with the PHERAstar.
Application note: Cellular dopamine and intracellular calcium signaling using the next generation HTS microplate reader
This application note highlights the direct optic bottom reading performance of the BMG LABTECH microplate readers in two different cell-based fluorescence intensity assays from Invitrogen.
Application note: Increasing throughput with dual emission AlphaLISA-AlphaPlex assay and simultaneous dual emission detection
Multiplexing AlphaLISA type assays will increase throughput while sample expenditure and costs are minimised. The ability of the PHERAstar FS microplate reader to perform simultaneous dual emission detection of this assay will allow users to double the information obtained from each well in the same amount of time as needed…
Application note: Miniaturisation of an HTRF methyltransferase assay that detects histone modifying activity
High throughput screening is mostly done in pharmaceutical companies that test whole libraries of compounds. Reducing the assay volume will reduce operating costs. At the same time it is necessary to prove that the smaller volume will not have a negative impact on assay sensitivity and reliability.
Application note: NanoBRETTM assay for monitoring of ligand binding to GPCRs in live cells, using the CLARIOstar® and the PHERAstar® FS
Due to the crucial role of G protein-coupled receptors (GPCRs) in mediating cellular responses to external stimuli, these receptors have been and will remain a prime focus for medical research and the pharmaceutical industry for many years to come. Their importance is especially highlighted by the statistic that 30-50% of…
This webinar shines a spotlight on cell-based and biochemical high-throughput screening in 1536 well plates. Supported by BMG LABTECH, the webinar will take place on 30 October at 4:00pm (GMT).
Application note: NanoBRET™ assay quantitatively evaluates VEGF binding to the VEGFR2 in real-time in living cells
In this application note, we show how the signal of luciferase and fluorophore were acquired simultaneously with the PHERAstar microplate reader...
The PHERAstar FSX microplate reader has been developed to meet the requirements for advanced high throughput screening. The new laser for Time-Resolved-Fluorescence (TRF) assays enables fastest read times for measurement in 1536-well microplates while keeping an excellent assay performance...
Genetically-encoded biosensors from Montana Molecular allow for detection of GPCR signalling...