Drug Target Review – Issue 4 2018

Posted: 26 November 2018 | | No comments yet

In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.

Drug Target Review issue 4 2018

In this issue:

  • UNDER THE MICROSCOPE: Under the microscope: CROs and microplate reader requirements
    BMG Labtech
  • APPLICATION NOTE: Automated cell transfection and reporter gene assays
    Beckman Coulter 
  • IN-DEPTH FOCUS: Screening
  • ORGANOIDS: Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery
    Matthias Nees and Malin Åkerfelt, University of Turku, Finland
  • GPCR: New frontiers in G protein-coupled receptor drug discovery
    Christopher J. Langmead, Monash Institute of Pharmaceutical Sciences (MIPS) 
  • IN-DEPTH FOCUS: Hit-to-lead
  • APPLICATION NOTE: Direct measurements of cellular metabolism for identification
    of mitochondrial drug targets
  • IN-DEPTH FOCUS: Targets
  • PROTEOMICS: Proteomics: cracking the molecular mystery of diseases and therapeutics
    Anowarul Amin, National Institutes of Neurological Disorders and Stroke (NINDS), NIH – Bethesda, MD 
  • SUPPLEMENT: Application notes
    With contributions from Eppendorf, IDBS, Intellicyt, Sciex and ThermoFisher Scientific.


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