news
Nerve regeneration offers hope for blindness and paralysis
US researchers uncover that certain nerve cells that have the capacity to regrow, are necessary for axon regeneration, providing hope for conditions like blindness and paralysis.
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Targets
article
Breakthrough drug candidates and cancer treatment innovations
In this exclusive interview with Dr Paul Moore, Chief Scientific Officer from Zymeworks, we explore the impressive responses of Zymeworks' antibody-drug conjugate ZW191 in FRα-low expressing models, indicating its efficacy in treating various oncology indications.
news
Neurons that are responsible for recognition
Researchers from South Korea uncover that neurons in the hippocampus play a crucial role in assigning positive value through interactions with others.
article
Promising human antibodies fighting SARS-CoV-2
Scientists have discovered that a vaccinated San Diego resident has produced antibodies that are effective against multiple variants of SARS-CoV-2, including Omicron. The research also identified three antibodies that can neutralise the virus, giving new insights into different binding mechanisms with the SARS-CoV-2 spike protein. The findings could help to…
news
Novel mutation linked to late-onset Alzheimer’s disease
Chinese researchers discover a mutation, referred to as the "Shanghai APP" mutation, which has been linked to late-onset Alzheimer's disease and offers fresh insights into the disease's underlying molecular mechanisms.
news
Scientists create first humanised mouse model for rare genetic disease
German researchers have successfully developed mice with a defected human gene responsible for congenital adrenal hyperplasia (CAH), a rare genetic disease.
podcasts
Episode 19 – A current look into adoptive cell therapies
Tune into this podcast to hear experts discussing the current landscape of adoptive cell therapies!
video
Video: Using luciferase reporter cell lines for HTS readouts
This video reviews the uses and advantages of reporter cell lines in the context of cellular research and drug discovery.
news
New algorithm can predict diabetic kidney disease
Researchers from US and Hong Kong have found that a simple blood sample may help doctors catch kidney disease earlier in type 2 diabetes patients
news
Placenta’s role in genetic risk of schizophrenia
A recent study led by the Lieber Institute for Brain Development has revealed that over 100 genes associated with the risk of schizophrenia appear to contribute to the development of the illness primarily through their influence on the placenta.
news
New gene linked to Malaria parasite’s chloroquine resistance
Researchers have important implications for the ongoing fight against malaria, a disease that affects approximately 247 million individuals and causes over 619,000 deaths each year, predominantly among young children.
news
Gut bacterial interactions limit antibiotic efficacy on C. difficile
A recent study from the University of Wisconsin-Madison suggests that interactions between gut bacteria can influence the effectiveness of antibiotics against C. difficile infections.
whitepaper
Infographic: Targeted protein degradation
In this infographic, we discuss both inhibition and degradation, the advantages and challenges related to each approach and the key points you need to consider when designing your protein degraders.
article
Algae: a source for prebiotics and drugs to treat IBD
An increasing number of people worldwide suffer from inflammatory bowel disease (IBD). However, no treatment is effective for all patients. In this article, researchers working on the Algae4IBD project explain how algae may represent a valuable source of prebiotics and new therapeutic agents for IBD and other diseases.
article
Framework for understanding cell organisation and variation
From a database of more than 200,000 high-resolution, three-dimensional images of human induced pluripotent stem cells, researchers have devised a model to quantify cell shape and internal organization. Susanne Rafelski, Deputy Director of the Allen Institute for Cell Science, revealed details of their study to Drug Target Review.
