MUTYH variants implicated in a broader range of cancers
The discovery that one missing copy of MUTYH could increase the risk of cancers may lead to therapeutics against solid tumours.
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The discovery that one missing copy of MUTYH could increase the risk of cancers may lead to therapeutics against solid tumours.
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
Six molecules that had potent antibacterial effect against one of the world’s most dangerous antibiotic-resistant bacteria were generated.
Mutation in two copies of the IKBKB gene leads to abnormal function of regulatory T cells, causing psoriatic arthritis.
The discovery of two proteins that effectively mature hiPSCs into endothelial cells may have a range of research and clinical benefits.
New findings about how long genes become less active with age could impact treatments for neurodegeneration, among other conditions.
New understanding of the CRC and its interaction with STAT3 could lead to novel therapeutics and combination strategies.
Whole genome sequencing identified 17 significant variants associated with AD risk in five genomic regions.
Pharmacological concomitant therapies or further genetic improvement of CAR T-cells can increase their effectiveness against TP53-mutant AML cells.
New findings will enable the development of safer PARP inhibitors that inhibit PARP’s enzymatic activity without trapping it on DNA.
Researchers have discovered two distinct lineages of Fusobacterium nucleatum, which has great implications for colorectal cancer screening and therapeutics.
Using in situ sequencing, a collaborative research group analysed 260 genes and discovered new sub-structures in MS lesions.
The proof-of-concept study could lead to a cure for HIV that inactivates diverse strains across multiple cellular contexts.
The findings from DNA and RNA sequencing in primary and metastatic UTUC tumours could lead to strategies to improve patient outcomes.
Use of the whole liver could revolutionise the development of viral vectors, providing more effective treatments for inherited diseases.