Investigating neuron-OPC synapses in live tissue
Oligodendrocyte precursor cells and the synapses they form with neurons could be relevant to many disease conditions, including cancer.
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Oligodendrocyte precursor cells and the synapses they form with neurons could be relevant to many disease conditions, including cancer.
Using clinical E. coli bacteraemia isolates, researchers found that high-persister mutants evolved which contributed to antibiotic failure.
RBM5 removal from cells meant that HOXA9 mRNA levels were greatly reduced, which could lead to therapies targeting HOXA9-driven leukaemia.
Genetic factors that promote disease development accumulated in CD4+ T cells exhibiting specific gene programmes.
Genetic engineering created IgA antibodies that bind to the SARS-CoV-2 spike protein in a similar way to IgG antibodies.
Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.
A new blood panel test reports the tumour fraction and the tumour type of prostate cancer with a high level of accuracy.
Novel self-assembled amino acid-based nanoparticles, loaded with doxorubicin, could evolve cancer treatment.
Data from protein analyses, combined with data from patient journals, enabled the discovery of proteins that predict disease progression.
Researchers found that ANG in its mutated form slows stem cell differentiation, resulting in neurodevelopmental defects in adult nerve cells.
Using bioinformatics analyses, HK-CREs impact on cellular processes was studied, including their potential as housekeeping tumour suppressors.
A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.
A novel peptide can suppress MYC by binding directly to it with sub-micro-molar affinity, advancing cancer drug development.
Adding a biodegradable polymer at the hinge and near hinge regions of trastuzumab enabled its movement across the blood-brain barrier.
Proximity labelling and single-particle tracking demonstrated that effectors in bacteria bind to mobile injectisome components.