New insights into the origins of mutations in cancer
Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
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Therapeutic RNA corrects splicing defect that causes familial dysautonomia
Scientists have identified a therapeutic RNA molecule that corrects the error in genetic processing that leads to familial dysautonomia...
UFD1 protein responsible for aggressive leukaemia
Researchers have identified a protein critical for the aggressiveness of T-cell leukaemia...
CRISPR used to improve red blood cell transfusion compatibility
Scientists have created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins...
Double-bridged peptides bind any disease target
Researchers have developed a new peptide format that they call double-bridged peptides...
Inhibiting NAT10 provides therapeutic target for HGPS
Scientists have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford progeria syndrome...
Lipid accumulation in the brain may be an early sign of Parkinson’s disease
A collaborative team of researchers has found that elevated levels of certain types of lipids in the brain may be an early sign of Parkinson's...
ALS researchers begin recreating human spinal cords on a chip
NIH-funded study closes in on personalised drug testing for neurological disorders...
Researchers develop new tools in the fight against diabetic blindness
A team of researchers led by the University of Missouri has employed a mouse model exhibiting diabetic retinopathy symptoms that could lead to future translational research studies.
Obesity inhibits key cancer defence mechanism
Obesity could enhance cancer development while aspirin might prevent it - a new insight into potential targets for cancer prevention.
Targeting telomerase as therapeutic strategy for melanoma
Combination therapy co-targeting the mitochondria enhances the antitumour effect of telomerase inhibition in NRAS-mutant melanoma.
Antibodies protect nerve-muscle connections in Lou Gehrig’s disease
A study identifies a novel treatment strategy that preserved neuromuscular synapses in a mouse model of aggressive ALS...
Genetic catalyst identifies the evolution of antibiotic resistance
Researchers have shown that it is possible to identify genetic catalysts that accelerate the evolution of antibiotic resistance in bacteria...
The role of ‘extra’ DNA in cancer evolution and therapy resistance
A team of scientists have reported that tumour progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA.
Study unearths how PKC zeta impacts colorectal cancer
Scientists in the United States have investigated the relationship between tumour suppressor, protein kinase C zeta (PKC zeta), and metastatic colorectal cancer.
