news
Assay may boost targeted treatment of non-hodgkin lymphoma
Better subtyping of diffuse large B-cell lymphomas can enhance diagnosis and guide treatment...
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Assays
An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
article
Expert view: Conquering late stage failures with advanced hit-to-lead techniques
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
article
Q&A: Implementing ADCC assays in QC: when donor variability isn’t an option
DiscoverX recently introduced the single donor-derived KILR CD16 Effector Cells to ensure assay reproducibility for screening, characterisation, and QC lot release of antibody drugs.
news
IONIS-HTTRx lowers deadly Huntington’s disease protein
The first drug targeting the cause of Huntington’s disease was safe and well-tolerated in its first human trial…
article
Expert view: Addressing the big challenges in drug screening
One of the biggest challenges facing drug discovery across all therapeutic modalities (small molecule, biologics, and cellular) remains the balance between physiological relevance and throughput.
whitepaper
Application note: Screening for inhibitors of PD-1 and PD-L1 binding with AlphaLISA technology
In this application note, PerkinElmer demonstrate the utility of an AlphaLISA assay for screening biotherapeutic antibodies and compounds that block binding of human PD-1 and PD-L1.
news
DNA mutations shed in blood predicts response to immunotherapy
Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...
news
Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017
Charles River Laboratories International, Inc. announced that its team of neuroscience drug discovery experts is presenting 27 scientific posters, both independently and collaboratively with clients, at Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience (SfN).
webinar
Implementing ADCC assays in QC: When donor variability isn’t an option
6 October 2017 | By DiscoverX Corporation
In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.
whitepaper
Whitepaper: Advancing therapeutic antibody discovery with multiplexed screening
In this whitepaper, IntelliCyt Corporation describe how the iQue Screener is used to perform multiplexed screens for antibody binding to either cell surface or to circulating target antigens...
whitepaper
Application note: Multiplexed detection of mouse cytokines using QBeads and the iQue Screener
This application note illustrates the value of multiplexing, rapid sampling, and assay miniaturisation using QBeads on the iQue Screener...
whitepaper
Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity
In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...
webinar
Webinar: Phenotypic assays for CNS disease drug discovery
21 September 2017 | By Charles River Laboratories
In this webinar, we highlight in vitro models and phenotypic assays to discover and validate novel targets and promising lead molecules...
whitepaper
Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
