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Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin -- the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes.
This technical note offers practical tips for facilitating the use of Thermo ScientificTM VarioskanTM LUX multimode reader and InvitrogenTM EVOSTM FL Auto Cell Imaging System with the goal of achieving successful cellular quantification and imaging of mammalian cells in microplate-based assays...
24 March 2017 | By IntelliCyt
The fastest way to the best clones...
Dr Sheraz Gul, Head of Assay Development and Screening at the Fraunhofer Institute for Molecular Biology and Applied Ecology, answers questions on assay procedures...
HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole animal screening assay formats. Horst Flotow, from Hit Discovery Constance, discusses the benefits and practicalities of, and recent progress in, whole animal screening. Madhu Lal-Nag, National Center for Advancing Translational Sciences, and Anton…
Monitoring cellular drug permeability and target engagement enables assessment of compound efficacy and confirmation of mode of action. InCELL Pulse target engagement assays provide the ability to confirm compound cell entry and target engagement while overcoming limitations of current target engagement assays...
With an increasing industry focus on antibody drugs, there is an ever greater need for functional bioassays that interrogate the various mechanisms of action (MOA) for the therapeutic antibody...
The S3e Cell Sorter demonstrates its utility in performing high purity sorts of adherent cells that express intercellular florescent proteins...
Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action...
4 October 2016 | By Cisbio Bioassays
A line of high quality products have been developed, addressing biomarkers to meet the needs of multiple therapeutic areas such as inflammation, oncology, metabolic disease or CNS...
Over the past few years several factors in the drug discovery industry have come together to drive an increased interest and subsequent surge in the use of high-content imaging. These include the high costs of attrition in the clinic due to lack of efficacy; increased hurdles and rising costs to…
This whitepaper highlights how commercial tools can reduce assay development time and enable a biologic developer to get to market or submission before competitors...
In this Assays In-Depth Focus: "Finding a cure for neglected tropical diseases with cell-based assays", plus "The relevance of homogeneous radiometric assays in modern drug discovery"...
23 February 2016 | By DiscoverX Corporation
PathHunter cell-based pharmacotrafficking assays provide a simple and quantitative tool for broad pharmacological characterisation and interrogation of compound function in disease processes associated with protein trafficking and internalization due to protein misfolding...
19 February 2016 | By DiscoverX Corporation
PathHunter® Checkpoint Assays enable screening and potency assays for the development of immunotherapy drugs...
