In non-human primates, researchers have found that mesenchymal stem cells were effective at strengthening the immune response to HIV.
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A team of researchers has shown that injection of cholangiocyte organoids in human livers ex vivo can repair the organs’ bile ducts. In this article, Dr Fotios Sampaziotis explains how his team’s study provides the first proof-of-principle for the efficacy of cellular therapies using organoids in human.
By editing out a set of proteins on the surface of human pluripotent stem cells, researchers have ensured they will be not be rejected by the body's immune system.
Ursolic acid was shown to halt the progression of chronic multiple sclerosis (MS) and reverse the damage already caused in a mouse model of the disease.
Researchers exploring how stem cells can be used discovered that cardiopoietic stem cells could repair in tissue in mouse models of heart attacks.
Scientists have showed that a three inhibitors (3i) cocktail could reprogramme fibroblasts to a naïve embryonic stem cell-like state and remove disease-associated epigenetic changes.
Rodent models of pulmonary fibrosis have been used to show that lung spheroid cell secretome therapy is as effective as stem cell secretome treatment.
Researchers have shown that by effectively resetting the microglia, recovery of mice after a traumatic brain injury (TBI) was improved.
Research has shown that leaky gut, the break down of gut lining junctions, could be targeted to reduce inflammation using metformin using an organoid model.
A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.
Research determined macrophages’ role in forming a permanent cardiac scar after a heart attack, the researchers suggest altering this behaviour may make the scar temporary and allow restoration of heart function.
A promising route for tackling the often-fatal MERS-coronavirus (MERS-CoV) has been identified by researchers in Germany.
A study has demonstrated that a totipotency-inducing factor can reprogramme stem cells and induce totipotent-like states, possibly increasing their therapeutic potential.
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.