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New tools accurately illuminates intracellular phase separation
Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...
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Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
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Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.
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scRNA-seq technique improves efficiency and accuracy of single cell RNA sequencing
Single nucleotide variations could be the key to better identification of tumour subpopulations...
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Scientists pinpoint mechanism by which mutant p53 protein promotes cancer
Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.
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Droplet Digital PCR detects and quantifies cancer mutation
Two ddPCR-based assays were developed to detect the two mutations in the promoter region of the TERT gene, which could be used as biomarkers...
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Chromatin study unearths link between DNA-protein binding and cancer
A team of scientists led by Stanford University School of Medicine has identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers to predict cancer pathways and long-term patient outcomes.
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GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
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Protein sequencing method could transform biological research
A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time
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Novel DNA vaccine offers broad protection against Influenza-A H3N
Researchers developed a novel DNA influenza vaccine based on four micro-consensus antigenic regions selected to represent the diversity of seasonal H3N2 viruses...
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Key genomic differences in breast cancers of women of different ethnicity
Study of genomic data from breast cancers of Nigerian women, compared with American women, highlights significant differences that may help targeted treatment for the epidemic across Sub-Saharan Africa.
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DNA vaccine shows promise for cancer immunotherapy
DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...
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Mitochondrial diseases could be treated with gene therapy
Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases...
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Scientists develop means to manipulate nuclear pore numbers
Researchers in California have developed a method to facilitate control of nuclear pore numbers in cells. The capability is expected to glean valuable information to aid cancer treatment.
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
