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3D map of CVD genetic interactions could aid future treatments
A 3D map of genetic interactions in CVD could aid researchers investigating future treatments for heat attacks, heart failure and heart rhythm disorders.
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DNA
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Genomics in drug development and safety testing; from target identification to genomic toxicology
In the annual report of the Chief Medical Officer, 1 Dame Sally Davies has declared that we are part of ‘generation genome’ – the era in which we reap the rewards of our advances in genomic technologies and improvements in our understanding of the whole genome in human health.
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Administering hormones affects DNA
In an experiment with pigs, researchers have demonstrated for the first time that the administration of even extremely low doses of an endocrine disruptor - in this case, an endogenous oestrogen - leads to epigenetic changes in a pregnant sow’s DNA.
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Researchers reveal therapeutic target for Influenza A
Researchers show altering the molecular interactions between the flu virus and host genes stunts virus replication...
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Bioactivity profiling supporting the progression of phenotypic hits
Addressing the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation...
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Gene signature holds promise for early detection of active TB
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin.
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CRISPR-Cas9 tool could increase cancer risk
Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...
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p53 gene prevents cancer development
Scientists have discovered how the most important gene in preventing human cancer, p53, is able to stop the development of lymphoma and potentially other types of cancer...
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Genomic medicine may one day revolutionise cardiovascular care
A new scientific statement summarises the state-of-the-science of genomic medicine...
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Profiling the genome hundreds of variations at a time
A CRISPR-Cas9 high-throughput strategy creates the possibility to rapidly profile and identify genes and DNA sequence variations key to different traits and diseases.
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NMT molecule provides hope for common cold cure
Researchers have lab-tested a molecule that can combat the common cold virus by preventing it from hijacking human cells...
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NDF identified as the missing factor in gene activation
Scientists find the missing factor in gene activation...
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A link between Huntington’s disease and rheumatoid arthritis identified
Epigenomic analyses may lead to other unexpected findings and novel therapeutic drug targets for many diseases
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New insights into the origins of mutations in cancer
Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
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Scientists generate an atlas of the human genome using stem cells
Scientists have generated an atlas of the human genome using a state-of-the-art gene editing technology and human embryonic stem cells, illuminating the roles that our genes play in health and disease.
