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Researchers image structure of cancer metastasis target
The structure of a key receptor involved in tumour metastasis has been imaged in a study, providing opportunities to develop cancer treatments.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Mechanism behind Piezo proteins discovered using imaging technique
A new study has used a combination of imaging methods to understand how the Piezo protein works, improving research into treatments for conditions such as high blood pressure.
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Osteoporosis in mice reversed with new drug target
A pharmaceutical target has been identified by Duke University that, when activated, can reverse bone degradation caused by osteoporosis.
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Revealed autophagy mechanism is potential dementia target
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
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Link between immune cells and Alzheimer’s discovered
Researchers have found that the presence of microglia brain cells allowed plaques to form in the brains of rodents, leading to Alzheimer’s disease.
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Blocking mechanism in skin cancer provides potential drug target
A study has revealed a drug target for skin cancers which regulates the differentiation of cells and the roles they conduct in the body.
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Study finds inhibiting inflammatory pathway could be brain metastasis target
Researchers have revealed a key inflammation mechanism that contributes to melanoma brain metastasis and could be a therapeutic target.
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Key mechanism in tuberculosis survival discovered
A new study has revealed that M. tuberculosis uses a unique type of antacid which gives immune cells indigestion, enabling the bacteria to survive.
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Researchers identify potential enterovirus drug target
A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target.
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Beyond the phenotype: using AI to better understand disease
Claus Bendtsen at AstraZeneca reveals how AI can be used to improve our understanding of disease, to help identify the causes of conditions and aid in drug discovery.
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Electrical channels in retina could play role in degenerative diseases
Researchers have discovered electrical channels important in sensory cell renewal which could be studied further to develop therapies for retinal diseases.
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Fruit fly model for studying uric acid diseases developed
Researchers have created a fruit fly model to investigate uric acid-related diseases such as diabetes to aid in drug development.
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Applying AI language translation to the creation of new pharmaceuticals
Designing new drug molecules is crucial to R&D. Dr Sam Genway suggests that one way to improve and speed up this process is using AI inspired by language translation.
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Researchers identify potential drug target for depression in primates
A study has discovered a molecule key in neuronal growth that could be used as a drug target to treat anxiety-related diseases.
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Process for rejuvenating aged rat brain stem cells discovered
A research team has developed a method for regenerating old brain stem cells from rat models, which could be used to treat age-related brain diseases.
