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Integrated drug discovery panel – your questions answered!
28 September 2017 | By Charles River
During this peer panel discussion, team members from Charles River discussed their views and strategies on Drug Discovery...
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In Vitro
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Exosomes identified as the missing link to insulin resistance
Researchers have identified exosomes as the missing link in diabetes...
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Expert view: Innovations in 3D
Physiologically relevant models to evaluate the effects of drug candidates early in the drug discovery and development process are becoming increasingly important to develop. Various 3D cell/tissue models have emerged offering relevant environment for ex vivo assays, but significant progress is required to streamline and automate the end-to-end workflow. Several…
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Polyphor achieves first milestone from Wellcome for antibiotic development
Polyphor achieves first milestone from Wellcome Trust for the development of antibiotics against Gram-negative multi drug - resistant pathogens...
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Nanoparticle aggregates for destruction of cancer cells
An international team has shown that it is possible to mechanically destroy cancer cells by rotating magnetic nanoparticles attached to them in elongated aggregates.
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Collaborations in early drug discovery
The earliest phases of drug discovery used to be confined to research divisions of large pharmaceutical companies...
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A focus on international regulations on IVD
SMi Group’s 3rd In Vitro Diagnostics conference will be take place on the 14th & 15th of June in London, bringing together global leading experts within the medical industry as they focus on the latest international trends within the field...
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Premature cell differentiation leads to disorders in pancreatic development
Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…
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3D bioprinted human cartilage cells can be implanted
Swedish researchers at Chalmers University of Technology and Sahlgrenska Academy have successfully induced human cartilage cells to live and grow in an animal model, using 3D bioprinting.
webinar
Designing a Novel Cancer Drug: From Hit ID to Candidate
28 March 2017 | By Charles River
Discover how their multidisciplinary approach to hit ID, design and synthesis of novel chemical templates and development of targeted in vitro and in vivo assays resulted in the nomination of the first development candidate in just over two years...
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Envigo expands R&D capabilities in non-animal technologies
Envigo is helping to define the non-animal technologies regulatory environment, with its scientists currently sitting on OECD expert working groups...
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Zebrafish early-life stages as neurological screening and detection tools
Unforeseen efficacy and safety-related issues with drugs continue to be a major cause of their attrition, despite significant efforts that are expended to eliminate them prior to initiating clinical trials...
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Investigation of venom use in stem cell differentiation
Stem cells differentiate to form more than 200 specialised cells, including erythroid bodies, haematopoietic cells, myogenic cells, neural cells, signalling cells and structural cells, such as hepatocytes. Differentiation of stem cells triggers a number of variable changes in the cell, such as membrane potential, responsiveness to signal, metabolic activities, and…
