news
Enzyme opens door to new therapeutic targets for cellular stress
The activity of enzyme ATE1, as seen by US researchers, flags misfolded proteins for destruction and is enhanced by binding iron-sulphur clusters.
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Molecular Targets
webinar
Using integrative biophysical approaches to understand GPCR regulation by β-arrestins
30 January 2023 | By Thermo Fisher Scientific
Watch this webinar to learn how an integrated structural biology workflow can be used to get crucial structural insights on key protein targets that are of therapeutic interest.
news
Combination of MRI and MSI uncover molecular secrets of Alzheimer’s
US researchers will use a unique combination of imaging techniques (MRI and MSI) to study Alzheimer’s disease on a scale that has never been done before.
article
Activity-directed synthesis: a structure-blind, function-driven molecular discovery approach
An autonomous strategy for molecular discovery could enable the exploration of a far broader chemical space than is possible with conventional approaches. In this article, Niamh Morris from Rosalind Franklin Institute outlines why activity-directed synthesis (ADS) could be the answer, providing examples of how this technique has the potential to…
article
Drug Target Review Screening ebook 2022
In this ebook are articles on how artificial intelligence can be used to identify drug candidates, data-lead screening models and autonomous strategies for molecular discovery.
news
Peptides with anticancer potential discovered in new study
Researchers have found peptides that bind to chains of ubiquitin proteins in cancer cells, suggesting they could be used as a therapeutic strategy.
news
New treatment target discovered for sleep apnoea
A recent study in mice revealed that an ion channel already proven to affect blood pressure in obese mice plays a role in suppressing their breathing, influencing sleep apnoea.
news
New study expands range of potential Alzheimer’s drugs
Researchers have connected the loss of alpha-B insulin receptors in brain microvessels as contributors to insulin resistance and cognitive decline, with Alzheimer’s disease.
news
Enhanced reprogrammed heart fibroblasts delivered into heart muscle cells
UAB researchers have found that adding TBX20 to the reprogramming cocktail MGT 133 promoted cardiac reprograming.
news
New method to label proteins could help track disease
Scientists have developed a new method to study the proteins released by cells, which could lead to the development of new tools to track diseases including cancer.
news
Pre-clinical trials show drug inhibits inflammasome in COVID-19 cases
Anti-inflammatory effects of niclosamide, observed in a new pre-clinical study, were due to inhibition of the inflammasome, a protein complex presented in the interior of defence cells.
news
Cytokine offers promising therapeutic target against type 2 diabetes
Researchers have found that the GDF15 cytokine could have beneficial effects on the metabolism and reduce obesity.
article
Exploring gene interactions in influenza to improve accuracy of flu vaccines
Researchers from the University of Illinois at Urbana-Champaign found the evolutionary potential of influenza A virus haemagglutinin is extremely restricted by epistatic interactions with neuraminidase.
news
Target for possible osteoarthritis treatment found in RORβ protein
A new study has revealed that activating the RORβ protein could lead to a possible treatment and prevention for osteoarthritis.
news
Powerful computer modelling approach developed to simulate cells
A study has proposed a new technique for modelling living cells at atomic resolution, which could be used to research human health.
