article
Targeting cancer metabolism
Cancer cells are addicted to glucose and glutamine, which enables them to generate the energy and macromolecule synthesis intermediates to support their growth...
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
article
The importance of adequately triaging hits from HTS campaigns
High throughput screening (HTS) continues to be employed in drug discovery as the primary source of identifying chemical starting points for drug discovery and tool compounds for chemical biology, respectively. Although small molecule drug discovery efforts have focused largely upon enzyme, receptor and ion-channel targets, there has been an increase…
video
An Introduction to Avacta Life Sciences
This video introduces Avacta Life Sciences, part of Avacta Group plc and its flagship product, Affimers - a revolutionary new, engineered alternative to antibodies...
article
Human pluripotent stem cell-derived cardiomyocytes in drug discovery and development
Procedures for cardiac differentiation of human pluripotent stem cells (hPSCs) have greatly improved over the past few years. The facilitated derivation of hPSC-cardiomyocytes has enabled the thorough assessment of their physiology and manipulation of their properties. Moreover, patient-specific hPSCs generated through cellular reprogramming allow for cardiac disease modelling, discovery of…
article
Screening In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
In this Screening In-Depth Focus, high throughput screening is the topic focused on by Kenji Schorpp and Kamyar Hadian, Institute of Molecular Toxicology and Pharmacology, and Sheraz Gul, Fraunhofer Institute for Molecular Biology and Applied Ecology. They discuss the importance of the technique in drug discovery today as well as…
article
True screening for immunology: transforming science with a practical tool for large-scale discovery
10 June 2015 | By IntelliCyt Corporation
The immune system plays a vital role in keeping us alive but also participates in many diseases adversely affecting quality of life across the globe. It can be over activated, leading to a variety of inflammation and autoimmune diseases, or suppressed, leading to a vast array of diseases from AIDS…
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From hype to hope: challenging the norm in lead discovery
From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…
product
PerkinElmer EnVision® Multilabel Plate Reader
20 May 2015 | By PerkinElmer
EnVision® Multilabel Plate Reader provides high speed, ultra high-throughput and maximum sensitivity across all detection technologies, so that your high throughput screening applications...
product
Thermo Scientific Multidrop Combi Reagent Dispenser
23 April 2015 | By Thermo Fisher Scientific
The Thermo Scientific Multidrop Combi is a reagent dispenser offering unrivalled levels of flexibility and performance to meet the requirements of reagent dispensing in pharmaceutical and biotechnology laboratories...
product
Thermo Scientific Varioskan LUX Multimode Microplate Reader
23 April 2015 | By Thermo Fisher Scientific
The Thermo Scientific Varioskan LUX Multimode Microplate Reader is designed for bioscience researchers with a wide variety of needs...
article
Academic high-throughput screening; Opportunities for change
Tim Hammonds from Cancer Research Technology Discoveries explains how academic HTS laboratories came into being and outlines the challenges facing the new HTS model...
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The impact of phenotypic and functional screening in CNS drug discovery
Wolfgang Fecke and Christine Williams from UCB discuss the industry’s approach to drug discovery with costs escalating and output failing to achieve the corresponding increases in revenue...
article
Evaluation of a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening
This article evaluates a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening...
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Workshop Review: Cell-based Assays for Screening (December 2014)
Sheraz Gul, Head of Biology at Fraunhofer-IME SP, provides an in-depth review of the Cell-Based Assays for Screening workshop which took place in December 2014...
news
MRC Technology launches respiratory ‘Call for Targets’
2 March 2015 | By MRC Technology
Project focused on potential small molecule or antibody targets in pathways important in the development or progression of respiratory disease...
