Application note: Multiplexed detection of mouse cytokines using QBeads and the iQue Screener
This application note illustrates the value of multiplexing, rapid sampling, and assay miniaturisation using QBeads on the iQue Screener...
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Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity
In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...
Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
Application note: KingFisher Presto sample purification system
In this application note Thermo Fisher Scientific compare data from the KingFisher Flex and KingFisher Presto instruments. Our results clearly indicate that the instruments produce equivalent yields and quality of extracted products. DNA extraction from human whole blood is shown as an example...
Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays
In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...
Paper: Acquisition and reversal of visual learning in CVN mice
Peer-reviewed paper on how touchscreen testing is a translational tool to assess cognitive function in a mouse model of Alzheimer’s disease...
Review: Protein misfolding in neurodegenerative diseases
Peer-reviewed publication on new strategies to target misfolded protein aggregates at various steps of protein production and processing...
Application note: The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid handler
In this application note, Sheraz Gul (Fraunhofer-IME SP), Markus Wolf (Fraunhofer-IME SP), Enda O’Connell (National University of Ireland Galway) and Howard Fearnhead (National University of Ireland Galway), demonstrate that the Echo 550 Liquid Handler can precisely and accurately transfer nanolitre volumes of compound with acoustic energy in a completely contact-free…
Tech note: Practical tips for cellular quantification and imaging using Thermo Scientific Varioskan LUX multimode reader and Invitrogen EVOS FL Auto Cell Imaging System
This technical note offers practical tips for facilitating the use of Thermo ScientificTM VarioskanTM LUX multimode reader and InvitrogenTM EVOSTM FL Auto Cell Imaging System with the goal of achieving successful cellular quantification and imaging of mammalian cells in microplate-based assays...
Brochure: Custom Assay Development
The Custom Assay Development (CAD) program at DiscoverX develops tailor-made cell lines optimised for your needs, enabling you to jump start your drug discovery programs...
Application Note: IDEA Bio-Medical offers a new feature for spatio-temporal analysis of rare events measures, using high-content microscopy
IDEA Bio-Medical offers a new feature for spatial detection and characterisation of temporal kinetics of rare events using its advanced HCS system, WiScan® Hermes...
Application Note: Exploration of microbial communities using the Thermo Scientific Varioskan LUX Multimode Reader and the Invitrogen EVOS FL Cell Imaging System
This application note demonstrates the feasibility of combining the Thermo Scientific™ Varioskan™ LUX multimode reader and Invitrogen™ EVOS™ FL Cell Imaging System for the fluorescence-based quantification and imaging of complex biological systems, without requiring separate assay optimisation...
Booklet: InCELL Pulse™ Target Engagement Kinase Reference Set
Monitoring cellular drug permeability and target engagement enables assessment of compound efficacy and confirmation of mode of action. InCELL Pulse target engagement assays provide the ability to confirm compound cell entry and target engagement while overcoming limitations of current target engagement assays...
Application Note: An Easy-to-Use Assay to Measure Target Cell Death by Antibody Dependent Cellular Phagocytosis (ADCP)
With an increasing industry focus on antibody drugs, there is an ever greater need for functional bioassays that interrogate the various mechanisms of action (MOA) for the therapeutic antibody...
App Note: Determination of antioxidant capacity on the Thermo Scientific Varioskan LUX Multimode Reader
This application note describes a method to measure the ORAC of different food and beverage samples with a fluorometric assay...
