article

Hit To Lead In-Depth Focus 2017

Posted: 6 December 2017 | | No comments yet

In this In-Depth Focus we look at a pragmatic approach to hit validation following biochemical high-throughput screening as well as identification of hits and leads for human African trypanosomiasis.

Hit to Lead In-Depth Focus cover
  • A pragmatic approach to hit validation following biochemical high-throughput screening
    Progressing actives from a high-throughput screen (HTS) of a target protein into suitable starting points for lead identification is fraught with pitfalls. The volume and quality of the HTS output is a function of the quality of the screening library, as well as specific properties of both the target and the screening assay. Agnes Martin, Laurent Rigoreau and Sheila McLoughlin review the pragmatic approaches they have elaborated to validate the output of over 40 biochemical HTS campaigns against cancer targets.
  • Identification of hits and leads for human African trypanosomiasis
    Neglected tropical diseases affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. Sheraz Gul, Giulia Pasini and Maria Paola Costi review some of these compounds.

This In-Depth Focus is restricted - login or subscribe free to access

Drug Target Review 3 2018 coverThank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.

Why subscribe? Join our growing community of thousands of industry professionals and gain access to:

  • quarterly issues in print and/or digital format
  • case studies, whitepapers, webinars and industry-leading content
  • breaking news and features
  • our extensive online archive of thousands of articles and years of past issues
  • ...And it's all free!

Click here to Subscribe today Login here

 


Send this to a friend