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Streamlining Biomanufacturing of Personalised Cancer Immunotherapies with Synthetic DNA
13 October 2025 | By
A Synthetic DNA Approach for Speed, Scale & Flexibility
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Articles
Exploiting functional selectivity of GPCRs in drug development
The large family of pharmaceutical targets represented by G-protein coupled receptors (GPCRs) are usually involved in a number of intracellular effector pathways, leading to many cellular outcomes. In recent years it has been uncovered that different ligands of a given GPCR may engage the pathways selectively, in that ligands that…
Flow cytometry: Not just a box in the lab
Undoubtedly, you will have noticed the increase in the number of publications utilising flow cytometry, heard it mentioned more in meetings and probably even been targeted by several companies trying to sell you their latest cytometer. The rapidly advancing technology behind the cytometer and an increase in applications that use…
SOMAscan™ assay: a vital proteomic tool in drug discovery
21 September 2015 | By SomaLogic
The SOMAscan™ assay is a highly multiplexed, sensitive, quantitative and reproducible proteomic tool for discovering biomarkers for drug discovery...
The importance of measuring drug target residence times
21 September 2015 | By BioTek
The Synergy Neo2 Multi-Mode Reader is designed to provide high temporal resolution in drug target kinetics applications...
Enzymes: Ubiquitin-specific proteases as druggable targets
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
SSPC – advancing science from molecule to medicine
6 August 2015 | By Synthesis and Solid State Pharmaceutical Centre (SSPC)
Read how the Synthesis and Solid State Pharmaceutical Centre (SSPC) is positioning Ireland as a global hub for advanced pharmaceutical manufacturing...
Stem cells: maintaining hope and challenging hype
6 July 2015 | By Caroline Richards, Editor
Inspired by her attendance at ISSCR 2015, Editor of Drug Target Review, Caroline Richards, discusses stem cells and the rise of unregulated stem cell practitioners...
Targeting cancer metabolism
Cancer cells are addicted to glucose and glutamine, which enables them to generate the energy and macromolecule synthesis intermediates to support their growth...
The importance of adequately triaging hits from HTS campaigns
High throughput screening (HTS) continues to be employed in drug discovery as the primary source of identifying chemical starting points for drug discovery and tool compounds for chemical biology, respectively. Although small molecule drug discovery efforts have focused largely upon enzyme, receptor and ion-channel targets, there has been an increase…
Investigation of venom use in stem cell differentiation
Stem cells differentiate to form more than 200 specialised cells, including erythroid bodies, haematopoietic cells, myogenic cells, neural cells, signalling cells and structural cells, such as hepatocytes. Differentiation of stem cells triggers a number of variable changes in the cell, such as membrane potential, responsiveness to signal, metabolic activities, and…
Human pluripotent stem cell-derived cardiomyocytes in drug discovery and development
Procedures for cardiac differentiation of human pluripotent stem cells (hPSCs) have greatly improved over the past few years. The facilitated derivation of hPSC-cardiomyocytes has enabled the thorough assessment of their physiology and manipulation of their properties. Moreover, patient-specific hPSCs generated through cellular reprogramming allow for cardiac disease modelling, discovery of…
Drug Target Review – Issue #2 2015
10 June 2015 | By Drug Target Review
Included in this issue: Drug Discovery, Screening, Hit-to-Lead, Antibodies, Stem Cells, Kinases and much more...
Stem Cells In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
This Stem Cells In-Depth Focus features articles on stem cell-derived cardiomyocytes, and their use in drug discovery and development, as well as a look at how venom could be used in stem cell differentiation...
Screening In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
In this Screening In-Depth Focus, high throughput screening is the topic focused on by Kenji Schorpp and Kamyar Hadian, Institute of Molecular Toxicology and Pharmacology, and Sheraz Gul, Fraunhofer Institute for Molecular Biology and Applied Ecology. They discuss the importance of the technique in drug discovery today as well as…
Stem cells discoveries: Arming scientists with the tools they need
10 June 2015 | By Molecular Devices
Molecular Devices discusses stem cells research and the company’s latest technological advancements in this exciting field...
