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Researchers uncover new target to stop cancer growth
Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes that stimulate tumour progression...
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Cancer
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Human immune ‘trigger’ map paves way for better treatments
A discovery about how human cells are 'triggered' to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders...
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CRISPR-Cas9 tool could increase cancer risk
Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...
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p53 gene prevents cancer development
Scientists have discovered how the most important gene in preventing human cancer, p53, is able to stop the development of lymphoma and potentially other types of cancer...
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Scientists decode ASCT2 protein as possible cancer drug target
Scientists in the Netherlands have investigated the structure of the human glutamine transporter ASCT2 in a bid to generate leads for cancer drug development.
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Screening In-Depth Focus 2018
This In-Depth Focus reviews the history of cancer treatments, looks at improving the translation of disease biology though phenomics, and considers how to enhance cell bioprocessing through cell-based combinatorial culture.
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Scientists uncover steps to kinase enzyme activation
A new study by the University of Arizona (UA) suggests that revealing all the steps required to activate an enzyme called a protein kinase may help identify new ways to target cancer.
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Penn study finds that different diseases elicit distinct sets of exhausted T cells
Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.
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Researchers uncover up to 100 potential drug targets for cancer
In a new study based on mouse cells, researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.
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mEAK-7 gene could suggest path towards cancer therapies
Researchers have found mEAK-7 regulates the molecular process that dictates cell growth and human development...
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Tumour-like spheres help scientists discover smarter cancer drugs
Researchers are reporting an innovative new method to screen for potential cancer drugs...
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Elastic microspheres expand understanding of embryonic development and cancer cells
A new technique that uses tiny elastic balls filled with fluorescent nanoparticles aims to expand the understanding of the mechanical forces that exist between cells...
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Study offers new approach to starve p53 deficient tumours
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
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Taking the brakes off the immune system: modelling effects in non-clinical safety studies
This article focuses on how the immune system functions, the challenges that it presents to drug development and why there are such concerns around safety that need to be investigated in pre-clinical studies. Moreover, it covers the role of checkpoint inhibitors as an attractive target for cancer immunotherapy.
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New insights into the origins of mutations in cancer
Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
