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cardiovascular disease (CVD)

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New findings may lead to cardiovascular disease treatment

31 March 2022 | By Ria Kakkad (Drug Target Review)

New research has found that immune cells produce a chemical messenger that prevents heart disease–related inflammation

news

Model insight into blood enzyme Lp-PLA2 could aid cardiovascular health

6 January 2022 | By Mandy Parrett (Drug Target Review)

A new study in the US has used a computer model to reveal the mechanism of action of lipoprotein-associated phospholipase A2 – a biomarker for cardiovascular disease.

article

The potential of epigenomic medicine in cardiology

22 June 2021 | By Professor John Giannios (Learna)

Advances in genomic medicine are playing an increasingly important role in the field of cardiology. Better analysis and understanding of patient genomic and epigenomic information can enable more personalised patient treatment and medical intervention. Here, Professor John Giannios considers the potential to use genomic medicine to prevent, monitor, diagnose and…

news

Mitochondrial protein revealed as target for cardiovascular disease

3 December 2020 | By Victoria Rees (Drug Target Review)

According to new research, the protein ALDH4A1 is a possible therapeutic target and diagnostic biomarker for cardiovascular disease.

Three-dimensional (3D) illustration of amyloid beta plaques (brown mesh-like shapes) forming between neurons and disrupting their function. Amyloid plaques are a hallmark of Alzheimer’s Disease.

news

Developing drugs for disordered proteins

6 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.

coronavirus particles in blue with pink spike proteins on their surface

news

Chronic use of heart disease medications may increase the risk of severe COVID-19

24 March 2020 | By Hannah Balfour (Drug Target Review)

A researcher has revealed that angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) may increase the risk of severe lung complications in COVID-19.

red blood cells and platelets mixed together

news

Method to make integrin receptor-targeting drugs safer in future presented in study

5 February 2020 | By Hannah Balfour (Drug Target Review)

Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.

article

Genomic medicine: cracking genomes to cure ‘incurable’ diseases

17 September 2019 | By Pushpanathan Muthuirulan (Harvard University)

We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…

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cardiovascular disease (CVD)