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Improved understanding of the liver fibrosis process
Scientists have examined gene activity in mice models, noting important indicators of liver disease severity which may be used as therapeutic strategies.
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Exploring liver disease therapies
Ochre Bio is at the forefront of therapeutic innovation, focusing primarily on liver diseases. Their core mission revolves around the development of RNA therapies, primarily in the preclinical stage, using a 'human-first' approach. They employ real human tissue, such as 'liver slices' and whole human livers, in their preclinical pipeline…
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Revolutionary nanoparticles enable gene-editing in lungs
This article outlines the development of a new type of nanoparticle that can perform gene-editing in the lungs. Scientists from MIT and the University of Massachusetts Medical School have collaborated to create this Ribonucleic acid (RNA) delivery particles, which have the potential to revolutionise the treatment of lung diseases such…
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Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers
Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.
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CRISPR ‘minigene’ used to prevent genetic liver disease in mice
Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
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Phage therapy shows potential to treat alcoholic liver disease
Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.
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3D liver tissue made from stem cells show promising support of liver function
Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...
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E06 antibody blocks inflammation from hardened arteries and liver disease
Study uncovers new potential therapeutic approach for a number of diseases linked to inflammation, including atherosclerosis, aortic stenosis and hepatic steatosis...
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Alpha-1 antitrypsin deficiency shows promise in rare liver disease
Nuclease-free gene editing has been found to correct mutated cells ...
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New drug targets for a rare kidney and liver disease
In a joint international study, researchers have collaborated to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease...
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Scientists discover immune system blind spot in hepatic cirrhosis
20 July 2016 | By Victoria White, Digital Content Producer
The discovery could lead to new treatments for bacterial infections, a leading cause of death in hepatic cirrhosis, without the need for antibiotics...
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Strategies for identifying predictive biomarkers of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD), a consequence of sedentary life styles and high fat diets, has an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within genes such as PNPLA3, TM6SF2, APOC3, NCAN and PPP1R3B correlate…
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Forbion invests in Akarna Therapeutics’ $15 Million Series B Financing
16 February 2016 | By Victoria White
Akarna has said it will use the funds to accelerate the development of its lead FXR agonist drug candidate...
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JQ1 prevents and reverses liver fibrosis in mice
9 December 2015 | By Victoria White
The discovery, made by scientists from the Salk Institute, could help the millions of people worldwide affected by liver fibrosis and cirrhosis, caused by alcoholism and diseases like hepatitis...
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Functional human hepatocytes grown in the lab
30 November 2015 | By Victoria White
This groundbreaking development could help advance a variety of liver-related research and applications...