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Pulmonary fibrosis: new drug slows and reverses lung scarring
Researchers have identified a key cellular mechanism that drives pulmonary fibrosis and successfully blocked it in mice, reducing lung scarring.
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Pulmonary fibrosis
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Inside the immune ‘handbook’ set to disrupt fibrosis research
Nearly a billion people are affected by chronic organ scarring, yet treatments remain limited. Now, Duke-NUS researchers have compiled a scientific ‘handbook’ of immune cell insights that could fast-track breakthroughs in fibrosis therapy.
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Nasal spray gene therapy shows potential to treat lung diseases
Researchers at Mass General Brigham have developed a new gene therapy delivery system, AAV.CPP.16, that targets the lungs via nasal spray, which could offer a potential breakthrough in respiratory gene therapy.
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New collaboration targets key challenges in fibrosis treatment
Deep Science Ventures and General Inception are teaming up to tackle fibrosis. Together, they aim to create a company focused on developing new treatments for fibrotic diseases.
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New insights on the structural biology of medical cannabis
French researchers underwent a structural study showing that THC cannabinoids inhibit a human enzyme called autotaxin.
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Lung-on-a-chip models enable advanced study of immune response
Researchers have reviewed lung-on-a-chip technologies, finding they are useful for representing the various disease pathologies.
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Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients
Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
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Using genetics to identify drug targets for fibrotic lung diseases
Researchers recently conducted a genome-wide association study (GWAS) to identify factors that increase susceptibility to the incurable lung condition idiopathic pulmonary fibrosis (IPF). Here, Dr Richard Allen shares some of the study’s key findings.
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Inhaling stem cell secretome could be a more effective pulmonary fibrosis treatment
Rodent models of pulmonary fibrosis have been used to show that lung spheroid cell secretome therapy is as effective as stem cell secretome treatment.
