news
Mavoglurant could improve eye gaze in fragile X patients
A first stage trial involving the experimental drug mavoglurant has shown early success in the treatment of gaze avoidance in fragile X syndrome patients...
List view / Grid view
Hit-to-Lead
news
‘Hidden pocket’ could be targeted to treat strokes
Researchers have identified a tiny hidden pocket on the NMDA receptor that could be targeted to treat strokes and seizures...
news
Nuclear tracers help assess new drugs for neurodegenerative diseases
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
news
Naturally occurring potent antibiotic revealed
A natural antibiotic was found to be made from an enzyme, through it triggering chemical reactions that help the production of the bacterial toxin...
news
Producing vaccines without the use of chemicals
Innovative new technology will use electron beams to produce inactivated vaccines quickly, reproducibly and without the use of chemicals...
article
Small molecules could have big benefits in the battle against cancers
Immunotherapy and targeted treatments, including targeted chemotherapy, continue to show great potential in cancer care. Future steps in their development will involve improving their ability to treat a wider range of cancers and a broader cross-section of the patient population, especially those for whom current treatments have shown limited efficacy...
news
Inhalable mRNA could treat lung disease
An inhalable mix of a polymer and mRNA molecules, used to produce luciferase, could be the method of treating lung diseases in the future...
news
Triple-negative breast cancer could be treated using experimental treatment
A mouse study has revealed that triple-negative breast cancer could be tackled by using recombinant Tinagl1 in therapy targeting signalling pathways...
news
The mysterious functions of the PCSK9 protein
Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
news
Potential drug targets found by muting large silent genes
Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
news
Human antibody discovery could save lives from fungal killer
Novel therapy uses antibodies cloned from patients who have recovered from an infection caused by the fungus Candida…
news
Compounds in coffee may fight Parkinson’s
Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...
article
Webinar highlights: Harmonising drug-target binding data analytics on a single platform
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
article
Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
article
PAINS management: an open source model to eliminate nuisance compounds
High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
