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Flow cytometry: breaking bottlenecks in drug discovery and development

20 September 2016 | By ,

The discovery and development of novel drug candidates is a highly complex, time-consuming and expensive process. Pharmaceutical scientists and clinicians should, therefore, reevaluate and modify the existing standard platforms and increase their uptake of robust advanced technologies such as flow cytometry to overcome the bottlenecks in these processes...

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CRISPR technology inactivates cancer mutations

1 September 2016 | By Niamh Louise Marriott, Digital Content Producer

CRISPR/Cas9 is likely one of the most revolutionary tools in biotechnology, with tremendous implications for a broad range of biological and medical disciplines. As programmable scissors this technology allows cleavage of DNA at predefined sites in the genome of cells...

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CRISPR gene editing could treat sickle cell disease

15 August 2016 | By Niamh Louise Marriott, Digital Content Producer

Foetal haemoglobin lacks beta sub-units and has gamma sub-units instead. Thus, beta-thalassemia or SCD–associated mutations, which impair the production or function of the beta sub-unit, do not cause problems with foetal haemoglobin, which can transport oxygen effectively in adults...

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Flu vaccines fail to protect obese mice

8 August 2016 | By St. Jude Children’s Research Hospital

Using vaccines prepared from killed viruses, the scientists targeted an influenza A H1N1 seasonal flu strain, finding that obese mice are not protected against influenza infections through vaccines, raising concerns about vaccine response in obese humans, who are known to be at an increased risk for severe flu...