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Deactivating gene could boost immunotherapy for head and neck cancer
Inhibiting the KDM4A enzyme slowed the growth of head and neck cancer in mouse models, also demonstrating promise to aid immunotherapy.
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Lung-on-a-chip models enable advanced study of immune response
Researchers have reviewed lung-on-a-chip technologies, finding they are useful for representing the various disease pathologies.
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Infographic: Proteogenomics strategies
Why you should link genomics with proteomics to accelerate the search for effective drug targets.
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Polymerised oestrogen provides neuroprotection in pre-clinical study
The polymerised form of oestrogen has shown success in mice at preventing further damage to the spinal cord after injury.
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‘Zinc finger’ gene therapy could help to treat Alzheimer’s disease
Promising results have been shown in an animal model of Alzheimer's disease treated with zinc finger protein transcription factors.
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SARS-CoV-2 variants: the role of sequencing and vaccine development
Professor Martin Michaelis and Dr Mark Wass explain why new SARS-CoV-2 variants are emerging around the world and how vaccines will have to adapt in response.
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Catalogue: Nuclease-Free tubes, tips & buffers
Working with RNA requires rigorous nuclease contamination controls in place. Stock up on Nuclease-Free tubes tips and buffers #Back2Lab
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Rhesus macaque model of Alzheimer’s disease developed
Scientists have developed a model of the early stages of Alzheimer's disease in rhesus macaques to better test new treatments.
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Team uses antibodies to tag disease-related proteins for destruction
Researchers have developed a technique utilising antibodies to tag disease-causing proteins, to treat the underlying causes of disease.
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Possible method to apply CAR T-cell therapy to solid tumours developed
Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.
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Researchers develop model of early human embryo from skin cells
Scientists have created the first model of early human embryos by reprogramming fibroblasts into a blastocyst-like structures.
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A strategy to cloak gene therapy AAV vectors from immune responses
Dr Ying Kai Chan discusses his latest research into how the delivery of AAV vectors for gene therapies can be made safer and more effective.
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Method for analysing sugar-protein interactions could enable better biologics
A novel machine learning method can explain how glycans stabilise proteins, aiding the discovery and design of protein-based drugs.
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Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2
SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.
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Researchers reveal how key enzyme APT2 works in cells
Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
