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Application note: Effect of perfluorinated alcohols in impurity analysis for synthetic oligonucleotides
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.
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Omics
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Application note: Effect of alkylamine based Ion-pairing reagents in analysis of siRNA
Silencing RNA, or siRNA, are short, double-stranded RNA molecules which are not only an important research tool in molecular biology, but also an emerging therapeutic modality.
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Application note: Comparison of fully porous and superficially porous particles for the analysis of synthetic oligonucleotides
Superficially porous particle technologies provide a reduced diffusion path in comparison with their fully porous counterparts minimising the resistance to mass transfer during chromatographic separation.
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Largest sequencing study of SARS-CoV-2 presents six separate strains
Researchers have sequenced SARS-CoV-2, revealing at least six strains with little variability, useful information for vaccine developers.
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New chemical screening method could reveal molecular glue degraders
A phenotypic chemical screen has been developed that could be used to discover molecular glue degraders which induce the degradation of target proteins.
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Near-identical protein on SARS and COVID-19 could be targeted by FDA-approved drugs
According to researchers, drugs that target envelope protein E on the SARS viral membrane could also be used to target a similar protein on COVID-19.
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New insights into human and mouse genomes published in NIH study
The third phase of the ENCODE project has been released, with new information on genes and their potential regulators in their respective genomes.
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Technique to visualise hundreds of genomes simultaneously developed
A new technology named OligoFISSEQ has been created which can image and three-dimensionally map the genomes in hundreds of cells at the same time.
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Breakthrough made in herpes antiviral molecule development
Researchers have created a new method of potentially treating herpes virus, by targeting the physical properties of the viral genome.
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Team redesigns COVID-19 Spike protein for more stable vaccines
Researchers have modified the COVID-19 Spike protein for use in vaccines, which produces up to 10 times more protein than that of an earlier synthetic versions.
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Novel CRISPR C-to-G DNA base editor developed by researchers
A new CRISPR technology has been created to understand mutations based on cytosine to guanine base changes and minimise unintended "off-target" mutations.
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Synapse protecting protein could be a target for Alzheimer’s therapies
Researchers suggest the SRPX2 protein, which inhibits complement system-dependent synapse removal could be a target for novel Alzheimer’s and schizophrenia therapies.
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Toxoplasma gondii hijacks host stress mechanisms to spread through the body
A new study reveals that the Toxoplasma gondii parasite acts through the IRE1 protein to cause infected cells to migrate through the body, spreading the parasite.
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Novel protein inhibitor improves immunotherapy in squamous cell carcinoma
Researchers reveal a combination of PD1 immunotherapy and BMI1 protein inhibition eliminated cancer stem cells and prevented cancer recurrence in a mouse model.
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Nanoparticle COVID-19 vaccine elicits immune response in pre-clinical studies
The vaccine candidate repRNA-CoV2S elicited both antibody and T cell responses after just two injections in mice and macaques.
