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Application note: Effect of perfluorinated alcohols in impurity analysis for synthetic oligonucleotides

Posted: 7 August 2020 | | No comments yet

Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.

Improved reliability to synthetic routes coupled with new drug delivery technologies has given a heightened level of interest in these clinically interesting targets. However, characterisation of oligos, specifically by ion-pair reversed phase liquid chromatography (IP-RPLC), can be quite challenging.











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