news
Autoimmune disorders could be treated with new compounds
New research could lead to novel treatments for autoimmune disorders and sheds light on the causes of autoimmunity.
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Screening
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AI-driven automated chemistry as a tool to accelerate drug discovery
Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
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Application note: Tools and protocols for high-content imaging and analysis
Integrating hardware, software and fluorescent labels for optimised HCA assay development.
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Application note: Laser technology for high-content imaging and analysis
Introducing the CellInsight CX7 LZR High-Content Analysis Platform - an updated version of our CellInsight CX7 instrument with advanced laser technology.
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Application note: Tools for 2D and 3D neuronal cell culture
From the B-27 Plus Neuronal Culture System to fluorescent probes for cell analysis. Publication history of B-27 supplements demonstrates that researchers are expanding its use, far beyond the long-term culture of rat hippocampal and cortical neurons.
news
Novel drug discovery approach for personalised mental health treatment
Researchers have developed a method that could drastically accelerate the search for new drugs to treat mental health disorders.
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Application note: Fuelling discovery with high-content imaging and analysis
HCA platforms automate image capture and data analysis, giving researchers the sample sizes and precise quantitation tools required for research.
news
Screening for genes to improve protein production in yeast
By silencing genes, researchers have increased the protein production in yeast, laying the grounds for engineering better yeast production hosts for industries producing biopharmaceutical proteins and industrial enzymes.
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HCA: Phenotypic fingerprint of cellular function
High-content analysis app note: Phenotypic fingerprint of cellular function following gene editing by high-throughput imaging acquisition and analysis.
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HCA Application note: New way of measuring synaptic function
High-content analysis: monitoring neurite morphology and synapse formation in primary neurons for neurotoxicity assessments and drug screening.
article
Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
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Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
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Video: High content imaging to examine RNA in cancer cells
Dr Kaylene Simpson, Peter MacCallum Cancer Center, describes their research using high content imaging to examine RNA in cancer cells.
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Video: 3D Culture Screening
Michael Johnson and his team at Visikol talk about the work they do as a contract research organization on 3D Cell Cultures and how they utilize High-Content Analysis / Screening to generate insights.
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The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
