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Researchers in the U.S. have identified that lymphatic vessels in the brain appear to play a crucial role in the development and progression of multiple sclerosis (MS), providing focus for new treatment research.
Due to the crucial role of G protein-coupled receptors (GPCRs) in mediating cellular responses to external stimuli, these receptors have been and will remain a prime focus for medical research and the pharmaceutical industry for many years to come. Their importance is especially highlighted by the statistic that 30-50% of…
Researchers from Texas University have used data from men with COPD to ascertain that testosterone replacement therapy could be beneficial...
Researchers have combined an open source software programme and commercially available hardware to image neuron activity at high resolution...
Researchers have condensed methods for identifying cancer gene mutations in cells into a single process, to aid understanding of tumours and improve treatment outcomes.
This webinar shines a spotlight on cell-based and biochemical high-throughput screening in 1536 well plates. Supported by BMG LABTECH, the webinar will take place on 30 October at 4:00pm (GMT).
Individualised therapies that target the specific genetic features of tumours have the potential to transform cancer diagnosis, treatment and care. However, several challenges remain before these approaches can be widely used in the clinic.
Explore the full kinetic and epitope diversity of large antibody libraries with high throughput Array SPR (Surface Plasmon Resonance).
For many years, screening assays have been based on high-content imaging systems. However, recent advances in the field of flow cytometry have meant that flow-based assays are now more prevalent. The power of flow cytometry to utilise multiple lasers, multiple fluorochromes and multiplexed assays has meant that assays are not…
Researchers have developed a see-through, dual-layered, mesh EEG device which is capable of measuring the electrical activity of individual neurons...
Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anti-cancer immunotherapeutics such as checkpoint modulation, adoptive cell therapy and bispecific T-cell engagers. While these approaches use different tactics to attack tumours, they often employ monoclonal antibodies to target…
Scientists have shared a new method that aims to accelerate the discovery of chemical compounds that inhibit a particular enzyme implicated in several cancers.
In this In-Depth Focus: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of human genetic diseases, and enabling biomarker discovery at single-cell resolution
This webinar, held on 28 June 2018, illustrated the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation. Keynote speaker Arsenio Nueda, Head of Molecular Biology at Almirall, responded as follows to questions posed during the webinar.
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
