news
Explosive cell death: inflammation-causing gene
WEHI researchers have found that a genetic change of MLKL increases risk of uncontrolled inflammatory response
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Targets
news
Proteolysis: new method developed to target cancer cells
Researchers have found that targeting chimeras with click-release proteolysis activates specific molecules that target cancer cells without harming health cells.
article
Antibody-drug conjugates payloads: then, now and next
Dr Nicolas Camper at CDMO Abzena and colleagues offer insight into the landscape of antibody-drug conjugates and how the therapy is evolving.
article
Artificial intelligence model revolutionises breast cancer surgery
Artificial intelligence (AI) and machine learning (ML) have been gaining significant attention lately, primarily in discussions about their responsible utilisation. However, these technologies possess a wide spectrum of practical applications, ranging from predicting natural disasters to addressing social disparities. Now, AI is making its mark in the field of cancer…
article
Developments in trapped ion mobility spectrometry
Torsten Müller from Bruker Daltonics shares how trapped ion mobility spectrometry (TIMS) fundamentally improves immunopeptidomics research and addresses key challenges in this rapidly expanding field.
news
Senescent immune cells promote lung tumour growth
A recent study sheds light on an unexpected discovery concerning macrophages, a vital type of white blood cell in the body's defence against infections and tumours.
webinar
Unlocking protein potential: liquid handling solutions for drug discovery
29 September 2023 | By Analytik Jena
Watch this webinar to learn how PROTACs are revolutionising drug discovery, and the critical role protein purification plays in the production of therapeutic proteins.
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Women in Stem with Dr Emily Leproust
This September edition of our Women in Stem series spotlights Dr Emily Leproust, CEO of Twist Bioscience. Dr Leproust began her STEM journey from a background in chemistry, eventually leading her to the forefront of DNA synthesis technology. She co-founded Twist Bioscience in 2013, now a thriving company reporting substantial…
news
Novel approach to overcome resistance to cancer drugs
Researchers at the University of Queensland have discovered a promising drug target capable of addressing drug resistance and preventing tumour regrowth in cancer patients.
whitepaper
ebook: Maximizing preclinical confidence in target efficacy and safety
This ebook outlines Euretos’ approach to target discovery and indication expansion. Whilst also discussing data-driven target selection.
news
Advancing obesity and diabetes therapy with brown fat cells
Researchers discover the intricate cellular signalling cues that orchestrate the formation of brown adipocytes in mice.
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Human neuronal cells: possibilities in drug safety testing
Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling. Early detection of neurotoxicity induced by potential new therapies is a major challenge, and hiPSC-neuronal cells may provide a solution. These cells demonstrate considerable promise for uncovering drug-induced perturbations to…
news
Engineered immune cells for improved cancer defence
A collaborative team has uncovered a method to extend the functionality of CAR-T cells.
news
PCOS: stem cell-derived components
Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder affecting millions of women worldwide, profoundly impacting their hormonal equilibrium, fertility, and overall quality of life. This enigmatic condition, characterised by diverse symptoms and complex underlying causes, has long eluded effective treatment.
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How organoids can redefine pre-clinical research
Organoids, lab-grown 3D structures that mimic human organs, are redefining preclinical research through bypassing the ethical and practical limitations of animal models. Technological advancements in organoid research, including automation and improved analytical tools, promise to unlock new possibilities by streamlining the application of these 3D structures to enhance drug development…
