CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer
Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...
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Parkinson’s UK Drug Discovery Manager joins DTR advisory board
Drug Target Review welcomes Janusz Kulagowski to its advisory board ...
Influenza viruses can help mutated viral proteins fold and function
A new study from has shed light on just how viruses evolve so quickly and offers a potential way to slow them down...
CYC065-eribulin combination therapy for triple-negative breast cancer identified
Researchers find novel combination disrupts multiple factors in aggressive breast cancer...
CCL11 may allow early CTE diagnosis
Researchers have identified a new biomarker for chronic traumatic encephalopathy that may allow the disease to be diagnosed during life for the first time...
Streamlined process opens drug development to a new class of steroids
Researchers have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries...
Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
MMP20 gene variants linked to high-risk childhood cancers
Paediatric researchers have identified common gene variants that raise the risk of an aggressive forms of childhood cancer...
National Physical Laboratory re-launched to improve access to health innovations
NPL's new approach informed by government priorities, consultancy with industry and the NHS, and a century of expertise, will see it focus on some of the world’s biggest health challenges, from supporting the diagnosis and treatment of cancer and dementia, to reducing attrition rates in drug development, to creating new…
MRI agent distinguishes aggressive from slow-growing breast cancer
Researchers have tested a new MRI contrast agent that pinpoints breast cancers at early stages and differentiates between aggressive and slow-growing types...
Exosomes identified as the missing link to insulin resistance
Researchers have identified exosomes as the missing link in diabetes...
Bryostatin-1 shows early promise for dormant HIV infection
Scientists have designed a synthetic molecule bryostatin-1 that can reactivate dormant HIV...
Genome editing reveals a role for OCT4 in human embryogenesis
Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...
Blocking ApoE4 may prevent nerve cell death in Alzheimer’s disease
Researchers have identified that the presence of ApoE4 exacerbates the brain damage caused by toxic tangles of tau protein...
B-cells promote melanoma progression and resistance to therapy
Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...
