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New UCLA drug could restore heart and organ function
UCLA researchers have developed a monoclonal antibody, AD-NP1, that blocks ENPP1 to enhance heart repair and reduce scar tissue.
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Scientists chart ovarian reserve to help advance new infertility treatments
UCLA scientists have created the first detailed map of how the ovarian reserve forms in primates, offering new insights – and potential new treatments – for infertility, polycystic ovary syndrome (PCOS) and hormone-related conditions.
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Preventing F-actin build-up improves drosophila healthspan
Disrupting F-actin in aged brains restored brain autophagy to youthful levels and reversed some cellular markers of brain ageing.
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GPNMB: a potential therapeutic agent for cardiovascular disease
Researchers reveal that GPNMB could be an effective therapeutic agent to improve cardiac function and prevent heart failure.
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Largest biobank of sarcoma-patient-derived organoids to date
Following high-throughput drug screening of the tumour organoids, an effective FDA-approved treatment was identified.
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Drug Target Review Imaging eBook
In this eBook, explore how cutting-edge imaging modalities can elevate your biomedical research.
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New detection system for viral infections helps vaccine and drug development
Out of the US, a newly developed a rapid, stain-free, and automated viral plaque detection system enabled by holography and deep learning, is a cost-effective way of observing the formation of viral plaques caused by viral infections over a layer of cells.
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Making lab-grown brain organoids ‘brainier’
UCLA-led team discovers that using early-stage stem cells is a key to producing structures that are reliable models of disease.
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Discovered receptor that could alleviate the need for chemotherapy
Researchers have shown that a synthetic IL-9 receptor allows T cells to fight against cancer without the need for chemotherapy or radiation.
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STING-activating drugs could customise cancer treatments
An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.
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Heating up tumours could make CAR T therapy more effective
When a heating technique called photothermal ablation was combined with the infusion of CAR T cells, it suppressed melanoma tumour growth for up to 20 days in mice...
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UCLA researchers correct mutation causing IPEX
A stem cell therapy rectifying the FoxP3 gene has been developed to treat IPEX, and has virtually cleared symptoms of the condition in mice...
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Technique to identify small molecules could speed up drug discovery
UCLA-led research has shown how using electron microscopes to analyse small molecules coud be beneficial in speeding up the drug discovery process...
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Scientists show combined immunotherapy treatment is effective against advanced melanoma
Study in the U.S. demonstrates successful treatment of advanced melanoma and metastatic cancer using a new bacteria-like agent combined with an immunotherapy drug.
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ImmunoPET imaging noninvasively pinpoints colitis inflammation
A novel PET imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease...
