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CRISPR

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CRISPR prevents hearing loss in mice

20 December 2017 | By Steve Bremer (Drug Target Review)

Researchers use CRISPR-Cas9 to target a mutation in the Tmc1 gene that causes the loss of hair cells in the inner ear.

Integrated Drug Discovery Panel – Your questions answered!

article

Q&A: Integrated drug discovery panel – your questions answered

11 December 2017 | By Drug Target Review

Drug discovery from concept to drug candidate has become a collective effort where multi-disciplinary project teams from CROs work with drug companies and academia to deliver clinical candidates, overcoming multi-factorial research obstacles along the way.

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Charles River adds ERS License to CRISPR/Cas9 service offering

7 December 2017 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced the expansion of its CRISPR/Cas9 service offering with the addition of a license from ERS Genomics Limited.

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Inhibiting METTL3 destroys AML cells without harming normal blood cells

28 November 2017 | By Dr Zara Kassam (Drug Target Review)

An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...

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AFM-CRISPR technique used to map DNA mutations

21 November 2017 | By Dr Zara Kassam (Drug Target Review)

Nanomapping technology may transform the way disease-causing genetic mutations are diagnosed and discovered...

news

CRISPR-carrying nanoparticles edit the genome

14 November 2017 | By Dr Zara Kassam (Drug Target Review)

New delivery system deletes disease-causing genes and reduces cholesterol...

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CRISPR-dCas9 reveals surprising insight into breast cancer development

13 November 2017 | By Dr Zara Kassam (Drug Target Review)

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...

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Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017

7 November 2017 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced that its team of neuroscience drug discovery experts is presenting 27 scientific posters, both independently and collaboratively with clients, at Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience (SfN).

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CRISPR engineered to edit single RNA letters

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

New 'REPAIR' system edits RNA, rather than DNA, without permanently affecting the genome...

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CRISPR used to identify drug target for bowel cancer

17 October 2017 | By Dr Zara Kassam (Drug Target Review)

CRISPR used to identify a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies...

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Modified CRISPR technique used to combat Parkinson’s disease

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

Biological engineers identify genes that protect against protein linked to Parkinson's disease...

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Microcapsules to enhance the efficiency of genome-editing

6 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...

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CRISPR-engineered cancer model to test therapeutics

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new technique for modelling leukaemia may aid drug discovery...

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CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...

news

Genome editing reveals a role for OCT4 in human embryogenesis

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...

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CRISPR