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Thalamus revealed as key area to target for certain brain disorders
Research shows that cells gather more data inside the thalamus than once believed, potentially changing medicines for brain disorders.
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Drug Leads
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Enzyme found to be an “Achilles’ heel” in ovarian cancers
Scientists have uncovered the crucial role of the enzyme NMNAT-2 in ovarian cancers, as well as other biomarkers that could lead to treatments.
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Greasy hair proves to be an unexpected possibility for obesity treatment
Researchers have revealed that the immune system of obese mice treated with TSLP released lipids through sebaceous glands.
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Farnesol shows potential to prevent and treat Parkinson’s disease
Researchers have added to evidence that farnesol prevents and reverses brain damage linked to Parkinson’s disease in mouse models.
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“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.
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Llama nanobodies could serve as new treatment for HCMV
Scientists have developed a “llama nanobody” that is capable of chasing out human cytomegalovirus (HCMV) so it is detected by the immune system.
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Algorithm helps find best drug targets for all COVID-19 variants
A new computer algorithm has identified highly conserved sequences in viral proteins that could make the best drug targets for COVID-19.
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Microcrystal electron diffraction could advance drug development
UK researchers have shown how microcrystal electron diffraction (MicroED) could obtain the structures of potential pharmaceuticals.
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Mefloquine identified as promising potential drug to combat COVID-19
Researchers in Japan propose that the antimalarial drug mefloquine could be repurposed to effectively treat SARS-CoV-2.
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Researchers discover class of drugs that could treat mantle cell lymphoma
A screening campaign has revealed that small molecule inhibitors of the SOX 11 oncogene are toxic to mantle cell lymphoma in vitro.
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The use of biophysical methods in the hit-to-lead process
Optimisation of a hit towards a lead happens in a variety of ways, as a lead needs to meet various criteria such as activity, affinity to the target, selectivity, solubility, permeability or metabolic stability to become a promising candidate. A balance between in vitro profiles and pharmacokinetic attributes has to…
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Senolytic drugs reduce COVID-19 symptoms in mice, study shows
In pre-clinical studies, senolytic drugs were found to reduce inflammation and death from COVID-19 in older mice.
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Screening identifies existing drugs as potential COVID-19 therapies
Scientists have found four clinically approved drugs and nine compounds with the potential to be repurposed as therapeutics for COVID-19.
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TEMPOL drug shows promise as antiviral treatment for COVID-19
The experimental drug TEMPOL has demonstrated antiviral activity against COVID-19 in a pre-clinical study in cell cultures.
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High-throughput screening platform detects henipavirus antivirals
A new high-throughput screening platform has been used to identify two compounds with antiviral activity against the Nipah and Hendra viruses.