Progress toward improved Wilson’s disease drug
28 June 2018 | By Drug Target Review
Researchers have conducted promising preclinical experiments on a compound that could be used to treat Wilson's disease...
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Drug Leads
Experimental drug combined with radiation extends the survival of GBM
28 June 2018 | By Drug Target Review
A new study has shown that an experimental drug known as AZ32 significantly extends the survival of glioblastoma multiforme, the most common and deadly form of brain cancer...
Scientists decode ASCT2 protein as possible cancer drug target
7 June 2018 | By Drug Target Review
Scientists in the Netherlands have investigated the structure of the human glutamine transporter ASCT2 in a bid to generate leads for cancer drug development.
Lymphatic endothelial cells are found to promote the spread of melanoma
4 May 2018 | By Drug Target Review
Scientists have investigated the mechanisms by which the lymphatic endothelial cells modulate metastasis in melanoma, providing new targets for therapy development.
New compound shows promise for stroke recovery
24 April 2018 | By Drug Target Review
Scientists in the U.S. have reported that an experimental compound appears to improve stroke outcome by reducing the destructive inflammation that can often continue months after a person has suffered the stroke.
Autoimmune disease research community gets boost from AMP RA/SLE study results
26 February 2018 | By Drug Target Review
Data from the Phase I study of collaborative industry partnership AMP are now available, meaning scientists can benefit from access to important research about Rheumatoid Arthritis and Systemic Lupus Erythematosus.
Antibodies provide potential targets for RSV vaccine development
26 February 2018 | By Drug Target Review
Scientists have found and characterised the activity of four antibodies produced by the human immune system that targets an important protein found in the respiratory syncytial virus...
BX795 molecule clears HSV-1 infection in human corneal cells
15 February 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers at the have identified a small drug molecule that can clear the herpes simplex virus-1 infection, making it a promising potential option for patients who have developed resistance...
Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
17 January 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
Identification of hits and leads for human African trypanosomiasis
13 December 2017 | By Dr Sheraz Gul, Giulia Pasini, Maria Paola Costi
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
NRF2 pathway provides new approach to cancer drug discovery
2 October 2017 | By Dr Zara Kassam (Drug Target Review)
Scientists have developed a promising new strategy for the discovery of novel anti-cancer therapies for non-small-cell lung cancers...
Scientists develop broad-spectrum inhibitors of influenza virus
29 September 2017 | By Dr Zara Kassam (Drug Target Review)
Scientists have developed broad-spectrum inhibitors of the influenza virus using artificial peptide molecules...
New headquarters in Scotland strengthens drug discovery research
10 August 2017 | By Dr Zara Kassam (Drug Target Review)
A provider of products and services for research in stem cells, drug discovery, human tissues and 3D cell culture has opened its European headquarters in Glasgow, UK...
Antibiotic insight may help in battle against bacterial resistance
19 July 2017 | By Dr Zara Kassam (Drug Target Review)
Bacteria or 'superbugs' that have adapted to resist multiple antibiotics are responsible for around 700,000 deaths globally a year; new types of antibiotics are urgently needed...
£1.5 million grant awarded to tackle psychosis in India
17 July 2017 | By Niamh Marriott (Drug Target Review)
University of Warwick researchers are to improve the lives of India's millions of psychosis sufferers.
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