Anti-inflammatory effects of niclosamide, observed in a new pre-clinical study, were due to inhibition of the inflammasome, a protein complex presented in the interior of defence cells.
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In the search for a rapid, easy way to identify drugs to fight SARS-CoV-2, researchers from across the US came together to develop and apply a high-throughput ADP-ribosylhydrolase assay, ADPr-Glo. Here, Dr Veronica Busa and Dr Anthony Leung from Johns Hopkins University describe the ADPr-Glo assay and how it can be…
Using screening techniques, researchers have identified the compound called AN15368 which works as an antiparasitic against Chagas disease.
A new screening study has shown that three natural compounds present in foods like green tea may be candidates for drugs that combat the coronavirus.
Researchers from the US have identified several new small molecules that can induce mitophagy in leukaemia cells.
With no current treatments for hepatitis A, scientists have discovered how a protein and enzymes interact to allow hepatitis A virus to replicate.
Researchers have found that blocking certain acetylcholine receptors in the lateral habenula made it harder to resist seeking cocaine in a rat model of addiction.
Researchers have linked resistance to kidney cancer treatment to low mitochondrial content in cancer cells
When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment.
Scientists from Karolinska Institutet have found mechanisms associated with a particular diabetes drug that can also help to protect against Alzheimer’s disease.
Scientists report news of a promising new compound that effectively blocks the activity of proteins on cells that are necessary for SARS-CoV-2 to cause infection.
By studying the gut microbes of rats, researchers discovered that a bacteria known as Coprococcus comes contributes to resistance to high blood pressure drugs.
Messenger RNA (mRNA) may be the ‘skeleton key’ that unlocks the door to fight latent viral infections that have plagued researchers for generations. Dr Sandeep Basnet, Director, Clinical Development at Moderna Therapeutics explores modern vaccine development and why mRNA is taking centre stage.
Researchers have developed a pH-sensitive drug delivery system in T cells using C-terminal dendrimers with Phenylalanine.
Researchers have developed a new method to screen drugs for Alzheimer’s disease, shedding light on why current drugs have failed and identifying novel drug targets.
Research in mice has shown that adding anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumour growth.