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The molecular link between ageing and neurodegeneration
Researchers have described the discovery of a molecular link between ageing and a major genetic cause of both ALS and FTD...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Experimental drug targets cancers associated with Epstein-Barr virus
An experimental drug is reported to have potential to treat Epstein-Barr virus related lymphomas by counteracting the cancer-promoting mechanisms of LMP2A...
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Cocaine relapse is reversed with BDNF microinjections in the brain
Researchers have discovered that a very common protein in the brain has an additional significant role in addiction relapse...
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Mouse models’ mimic lung disease
Researchers have finally been able to mimic IPF in mouse models - a debilitating disease, with no proper treatment and no cure...
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Anticancer drug as an alternative to liver transplant
Mouse models showed promise when an anticancer drug was used to treat liver failure, resulting in liver regeneration and preventing liver related death...
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Chemical that can kill glioblastoma cells identified
"As an experimental chemical, further rigorous testing and refinement of KHS101 is required before trials in people can begin.”
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RUNX proteins essential for DNA repair
The research team identified that the more the DNA was damaged, the more RUNX proteins bound to DNA repair intermediaries...
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Effective approach to optimising medicinal molecules
Computational methods accelerates and automates the process of optimisation of candidate molecules before performing preclinical trials...
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Targeting the growth signals of ‘undruggable’ cancers
Dr Bivona and his team showed that the growth of multiple cancers slowed by suppressing the signalling pathway using an experimental compound...
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Autoimmune response drives vision loss in glaucoma
New research shows that immune cells developed from early exposure to bacteria contribute to vision loss in glaucoma patients...
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Drugs in development for cancer may also fight brain diseases
PARP inhibitors show promise in preventing toxic accumulations of brain disease proteins in Penn research study...
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‘Drug cocktails’ could strengthen targeted cancer therapies
"Targeted therapies have revolutionised cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy..."
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New drugs targeting gut microbes may reduce the risk of cardiovascular disease
The new class of drugs are mechanism-based inhibitors which potentially interrupt the gut microbial pathway that produces TMAO...
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pH imbalance in astrocytes may lead to Alzheimer’s disease
The researchers found that 10 of the 100 most frequently down-regulated genes were connected with proton flow in the cell...
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miR-132 offers hope for novel Alzheimer’s treatments
The study of neuroprotective microRNAs like miR-132 may lead to new avenues for treating Alzheimer's disease and other tau pathologies...
