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Study uncovers therapeutic targets for aggressive triple-negative breast cancers
New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Mirror-image peptides of existing drugs provide longer-lasting therapeutic effects
Researchers have developed a new technology for creating more durable disease-fighting molecules which could lead to drugs with longer-lasting effects...
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DRD2 crystal structure provides antipsychotic drug development tool
Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...
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Blocking 20-HETE chemical counters the siren call of aggressive cancers
Scientists have successfully blocked the powerful call of two types of aggressive cancer – glioblastoma and breast cancer – in laboratory models; with evidence that inhibiting the chemical 20-HETE halts tumour growth.
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Cryo-EM reveals critical OST complex and potential drug target
Scientists have revealed the atomic-level structure of a molecular complex responsible for modifying proteins, paving the way for the development of new medications...
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Autism risk factor search aided by epigenetics study
Scientists have identified more than 2,000 regulatory regions involved in learning that correlate strongly with autism, suggesting future focus for autism research.
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Drugs targeting the cells circadian rhythm offers hope for glioblastoma
An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...
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Promising preclinical drug candidate suppresses HIV
A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
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Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
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A2aAR protein holds clues for better drug design
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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Machine learning approaches as tools to accelerate drug discovery
Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...
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IONIS-HTTRx lowers deadly Huntington’s disease protein
The first drug targeting the cause of Huntington’s disease was safe and well-tolerated in its first human trial…
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
