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DNMT3A crystal structure linked to cancer development
Scientists offer important information for understanding de novo DNA methlylation...
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Epigenetics
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SMi’s 9th annual RNA Therapeutics conference will take place in just 2 weeks!
Presenting issues and real-life examples within the RNA space, SMi welcome insights and discussions into new technologies for single-stranded RNA, epigenetics to develop first-in class drugs in oncology, patenting RNA Therapeutics and exploring the latest developments in delivery systems, including Exosomes and Nanocomplexes. Read on for your exclusive discount to…
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Study uncovers therapeutic targets for aggressive triple-negative breast cancers
New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...
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LiP-mass spectrometric analysis measures molecular interactions
Researchers have systematically analysed and quantified the interactions of all proteins with metabolites on the level of the whole proteome...
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Sirt2 enzyme identified as therapeutic target for diabetes
Researchers have identified the sirtuin enzyme as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting a potential therapeutic target for type 2 diabetes...
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ZNF274 deletion reverses Prader-Willi syndrome
Reversing the imprinting that causes Prader-Willi syndrome gives hope that epigenetic diseases can be cured...
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Autism risk factor search aided by epigenetics study
Scientists have identified more than 2,000 regulatory regions involved in learning that correlate strongly with autism, suggesting future focus for autism research.
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Epigenetic compound inhibits the growth of melanoma cells
Researchers have developed a compound that successfully inhibits the growth of melanoma cells by targeting specific epigenetic modifying proteins...
product
Alpha technology
3 January 2018 | By PerkinElmer
Alpha (Amplified Luminescence Proximity Homogeneous Assay) bead-based technology for no-wash assays.
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CRISPR-dCas9 reveals surprising insight into breast cancer development
Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...
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Expert view: Overcoming NGS obstacles
Using next-generation sequencing techniques enables pharmaceutical companies to explore the molecular landscape of disease initiation and progression with unprecedented clarity. Dr Sam Rulli, Product Manager at QIAGEN, provides his insight into the major challenges researchers face...
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Expert view: The future of single-cell sequencing
The power of single-cell sequencing and its application in the field of oncology remains a top opportunity for discoveries that could have a huge impact on improving human health worldwide. However, barriers remain before those studies can be furthered...
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Breakthrough method yields trove of neuronal subtypes and gene regulators
Researchers have discovered a trove of neuronal subtypes and gene regulators, using a new method they developed called snmC-seq...
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CRISPR-Cas9 repairs genetic mutation in human embryos
"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs
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DNA: discovering a new mechanism of epigenetic inheritance
Scientists have demonstrated the existence of transgenerational epigenetic inheritance (TEI) among Drosophila fruit flies...
