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New genes identified in children linked to stress & bipolar disorder
Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a new study...
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Gene Therapy
Gene Therapy is the introduction of normal genes into cells in place of missing or defective ones in order to correct genetic disorders.
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
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New chlamydia drug targets discovered using CRISPR and stem cells
Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...
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New angle of attack on spinal muscular atrophy (SMA)
Spinal muscular atrophy (SMA) in its most severe form is incurable and fatal in early childhood, but now researchers are mounting a multi-pronged attack for patients and their families.
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DNA: discovering a new mechanism of epigenetic inheritance
Scientists have demonstrated the existence of transgenerational epigenetic inheritance (TEI) among Drosophila fruit flies...
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Removing old cells could extend joint health & stop osteoarthritis
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
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New potential treatment for aggressive brain cancer in children
Using state-of-the-art gene editing technology, scientists have discovered a promising target to treat atypical teratoid/rhabdoid tumour (AT/RT) - a highly aggressive and therapy resistant brain tumour that mostly occurs in infants.
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Premature cell differentiation leads to disorders in pancreatic development
Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…
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Novel genes identified that help suppress prostate and other cancers
New genes which help prevent prostate, skin and breast cancer development in mice have been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators.
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Immunotherapy and gene therapy combination shows promise against brain tumours
The outlook for brain tumour patients is pretty negative, with the median survival rate for patients with glioblastoma multiforme, or GBM, a mere 14.2 months.
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UK biotech Orchard Therapeutics opens US operations in California
6 October 2016 | By Niamh Louise Marriott, Digital Content Producer
Foster City will serve as headquarters for Orchard Therapeutics North America, and will provide the central base for laboratory operations associated...
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Attendee list released for the Orphan Drugs & Rare Diseases 2016
13 September 2016 | By SMi
SMi Reports (13.09. 2016, London, UK): Alexion, BioMarin, Chiesi, MHRA, NICE to meet in London in October to discuss updates in the orphan drug landscape...
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How NIH’s $30 million research fund will help find HIV cure
20 July 2016 | By Niamh Louise Marriott, Digital Content Producer
The NIH recently awarded $30 million to advance science towards a cure for HIV. Drug Target Review caught up with the Wistar Institute‘s Dr. Luis Montaner, co-leader of the BEAT-HIV project...
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Mkx gene revealed as crucial for keeping tendons healthy
14 July 2016 | By Victoria White, Digital Content Producer
The Scripps Research Institute scientists behind the study say their findings may bring doctors closer to using gene therapies to grow and repair tendons...
