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Reference genome comparison finds exome variant discrepancies
Scientists have found differences in 206 genes between the GRCh38 (hg38) and GRCh37 (hg19) human reference genomes.
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Genetic Analysis
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Computational method developed to map chromosome folding in 3D
Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.
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Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
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Brochure: Diabetes Solutions
Solutions to aid understanding of cellular and molecular pathways in diabetes and translate these findings into prevention and treatment strategies.
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Genetic profile of skeleton osteocytes mapped for first time
Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.
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CRISPR reveals genes involved in zebrafish spinal cord regeneration
A CRISPR-Cas9 method has been used to identify which genes play a role in repairing zebrafish spinal cord injuries.
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UK Government to fund £37 million into genomics projects
UK Health Secretary Matt Hancock has announced £37 million of funding for genomics and data projects to support the life sciences sector.
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Gene changes caused by Spike protein could explain long COVID
Scientists have shown that the SARS-CoV-2 Spike protein can initiate gene expression changes, potentially explaining long COVID symptoms.
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Study points to treatment approaches for advanced small-cell lung cancer
Having sequenced samples of advanced small-cell lung cancer, researchers have identified patterns linked to resistance to certain therapies.
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Alliance to create atlas of human genetic variants launched
The Atlas of Variant Effects Alliance will develop a map of human genetic variants to advance the understanding and treatment of disease.
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Episode 1 – Dr Sri Gopal, Janssen Pharmaceuticals
Listen along to learn more about drug development for schizophrenia from Dr Sri Gopal, Head of Psychiatry R&D for Janssen!
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Researchers reveal 3D structure responsible for gene expression
Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.
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Researchers study iPSCs to uncover genetic causes of disease
Sequencing and transcriptome data on iPSCs has been used to identify correlations between genetic variants and expression patterns.
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Platform reveals insights into cancer genomics and personalised medicine
Researchers have developed a personalised medicine platform that could advance genomic medicine research for cancer.
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Altering balance of fibroblasts could prevent spread of colorectal cancer
Researchers have found that colorectal cancer-associated fibroblasts can be altered using a gremlin 1-neutralising antibody or by overexpressing meflin.
