news
Tracking SARS-CoV-2 evolution: notable mutations and potential targets
Researchers report that while the spike protein and RNA polymerase proteins have stabilised, other regions of the SARS-CoV-2 genome are becoming increasingly variable.
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Genetic Analysis
news
Researchers identify over 550 cancer-driving genes
Computational analysis has been used by researchers to examine 66 types of cancer and identify 568 genes that drive tumour development.
news
Drug target for spinocerebellar ataxia type 1 identified by researchers
A team has found that a mutation in the ATAXIN-1 gene causes spinocerebellar ataxia type 1 (SCA1), presenting a drug target for the condition.
news
Algorithm to predict sites of DNA methylation and drug targets developed
A machine learning algorithm that predicts sites of DNA methylation could aid in the identification of disease-causing mechanisms, say researchers.
whitepaper
Application note: The effect of column hardware on the analysis of synthetic oligonucleotides by LC-MS
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.
whitepaper
Application note: Effect of temperature on single stranded oligonucleotide analysis
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry. However, characterisation of oligos, specifically by ion-pair reversed phase liquid chromatography (IPRPLC), can be quite challenging.
whitepaper
Application note: Effect of perfluorinated alcohols in impurity analysis for synthetic oligonucleotides
Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.
whitepaper
Application note: Effect of alkylamine based Ion-pairing reagents in analysis of siRNA
Silencing RNA, or siRNA, are short, double-stranded RNA molecules which are not only an important research tool in molecular biology, but also an emerging therapeutic modality.
whitepaper
Application note: Comparison of fully porous and superficially porous particles for the analysis of synthetic oligonucleotides
Superficially porous particle technologies provide a reduced diffusion path in comparison with their fully porous counterparts minimising the resistance to mass transfer during chromatographic separation.
news
New insights into human and mouse genomes published in NIH study
The third phase of the ENCODE project has been released, with new information on genes and their potential regulators in their respective genomes.
news
Over 200 genes implicated in glioblastoma tumour growth
A study has identified more than 200 genes that drive the progression of glioblastoma and which the researchers say present drug targets.
news
Technique to visualise hundreds of genomes simultaneously developed
A new technology named OligoFISSEQ has been created which can image and three-dimensionally map the genomes in hundreds of cells at the same time.
article
Revealing the genetic signature of neurodegenerative disease
Which immune cells contribute towards immune-induced neurodegeneration and how could this knowledge enable conditions such Alzheimer’s and multiple sclerosis to be treated?
webinar
Mobile phase optimisation for oligonucleotide analytical methods by LC-MS
1 July 2020 | By Phenomenex
In this on-demand webinar, we provide an overview of nucleic acid therapeutics and discuss the chromatographic challenges associated with oligonucleotides. We also explore modulation of the mobile phase additives alkylamine ion pair and perfluorinated alcohols. Finally, we will show how optimisation of mobile phase can improve not only chromatographic performance…
news
Study identifies 68 genes associated with risk of severe COVID-19
A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials.
