news
Model insight into blood enzyme Lp-PLA2 could aid cardiovascular health
A new study in the US has used a computer model to reveal the mechanism of action of lipoprotein-associated phospholipase A2 – a biomarker for cardiovascular disease.
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Informatics
webinar
Chasing my Cure: Leveraging serum proteomics to identify novel therapeutic approaches and predictive biomarkers
4 January 2022 | By SomaLogic
Watch our on-demand one-hour session to discover groundbreaking work to advance precision medicine for Castleman disease.
podcasts
Episode 4 – LIMS systems with Tyler Pascoe & Matt Gruver, Thermo Fisher Scientific
In this podcast, join Tyler Pascoe and Matt Gruver from Thermo Fisher Scientific as they explore the new Watson LIMS software.
whitepaper
Application note: Competitive high-throughput analysis of kinase inhibitor binding kinetics
A microplate-based method for the determination of association and dissociation rate values in high throughput using a kinetic probe competition assay (kPCA).
article
Drug Target Review – Issue 4 2021
This issue includes articles that discuss the development of long-term 3D tissue cultures from human biopsy samples, the application of flow cytometry in drug discovery and automation for upstream processing in a biologics manufacturing environment. Also included are features on informatics, proteomics and CRISPR.
news
Researchers delineate novel COVID-19 subgroups in critically ill patients
The new study used sequence clustering analysis to identify four subgroups of COVID-19 to help match patients to specific treatments.
news
‘Transformational’ machine learning method may speed up drug discovery
Transformational machine learning (TML) learns from multiple problems and improves performance while it learns, potentially accelerating drug discovery.
article
Target safety assessments – identifying risk early
With an ever-increasing emphasis on minimising drug candidate attrition, scientists are focusing on target safety at earlier points in the research process. In this exclusive interview, Drug Target Review spoke with Dr Gordon Baxter, Chief Scientific Officer of Instem, to learn how target safety assessments can enable researchers to quickly…
news
Nanoscale “computer” a pivotal step for precision medicine
The study paves the way for the construction of complex nanoscale computers for the prevention and treatment of cancer and other diseases.
whitepaper
Brochure: Biologics workflow solutions brochure
Biologics solutions from discovery to manufacturing.
news
Machine learning models predict antibiotic resistance spread
Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.
news
Groundbreaking data tool may uncover novel class of GPCRs
A new computer-aided tool maps allosteric sites in G protein-coupled receptors to search for allosteric drugs to treat a range of diseases.
news
Algorithm identifies cancer drugs to treat pulmonary hypertension
Scientists have identified potential cancer drugs to treat pulmonary hypertension using experimental and computational approaches.
article
Are computer simulations the future of rapid COVID-19 drug development?
Researchers have visualised SARS-CoV-2 protein dynamics using in silico methods. In this article, Navodya Roemer explains how a team from the University of Warwick developed a computational strategy that could assist scientists in the production of new treatments and drugs for COVID-19.
news
Statistical model defines how ketamine anaesthesia affects the brain
An MIT study has used the first statistical model to finely characterise how ketamine anaesthesia affects the brain, possibly improving patient outcomes.
